Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 2/20 | 0.86 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.47 |
| ▸ | BRAF | P15056 | 6/20 | 0.46 |
| ▸ | KDR | P35968 | 6/20 | 0.46 |
| ▸ | ENPP3 | O14638 | 2/20 | 0.43 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.43 |
| ▸ | FNTA | P49354 | 1/20 | 0.43 |
| ▸ | FNTB | P49356 | 1/20 | 0.43 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.43 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.42 |
| ▸ | DPP4 | P27487 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18120682 | 0.93 | DHODH (1.00) | DHODHEPHX2DPP4 | |
| SCHEMBL8857884 | 0.93 | DHODH (1.00) | DHODHEPHX2DPP4 | |
| SCHEMBL9017576 | 0.90 | DHODH (0.69) | DHODHEPHX2ENPP3ENPP2ENPP1 | |
| SCHEMBL9017542 | 0.89 | DHODH (0.67) | DHODHEPHX2BRAFKDR | |
| SCHEMBL9017543 | 0.87 | DHODH (0.65) | DHODHEPHX2FNTAFNTB | |
| SCHEMBL9157076 | 0.87 | DHODH (0.64) | DHODHEPHX2FNTAFNTB | |
| SCHEMBL9017605 | 0.85 | DHODH (0.61) | DHODHEPHX2BRAFKDRFNTA | |
| SCHEMBL9017564 | 0.85 | DHODH (0.61) | DHODHEPHX2FNTAFNTB | |
| SCHEMBL9017561 | 0.85 | DHODH (0.61) | DHODHEPHX2FNTAFNTB | |
| SCHEMBL9017547 | 0.85 | DHODH (0.61) | DHODHEPHX2FNTAFNTB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0533573-B1 | Derivatives of 3-cyclo alkyl-propen-2-amide, their tautomeres and salts and their use as antiinflammatory agents | ROUSSEL UCLAF (FR) | 1996-12-04 | — | — | EP | disclosed |
| US-5389652-A | Antiinflammatory agent | ROUSSEL-UCLAF (FR) | 1995-02-14 | — | — | US | disclosed |
| US-5312830-A | Antiinflammatory agents | ROUSSEL-UCLAF (FR) | 1994-05-17 | — | — | US | disclosed |