Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 3/20 | 0.65 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9017562 | 0.95 | DHODH (0.59) | DHODHEPHX2TP53MAPK10CYP2C9 | |
| SCHEMBL9017616 | 0.95 | DHODH (0.59) | DHODHEPHX2TP53MAPK10CYP2C9 | |
| SCHEMBL9310653 | 0.94 | DHODH (0.58) | DHODHEPHX2TP53MAPK10CYP2C9 | |
| SCHEMBL25813258 | 0.92 | DHODH (0.74) | DHODHTP53MAPK10CYP2C9CYP2C19 | |
| SCHEMBL27242987 | 0.92 | DHODH (0.74) | DHODHTP53MAPK10CYP2C9CYP2C19 | |
| SCHEMBL9157076 | 0.90 | DHODH (0.64) | DHODHEPHX2TP53RAB9AMAPT | |
| SCHEMBL8614830 | 0.89 | DHODH (0.69) | DHODHTP53MAPK10CYP2C9CYP2C19 | |
| SCHEMBL9017561 | 0.88 | DHODH (0.61) | DHODHEPHX2GAARAB9AMAPT | |
| SCHEMBL9017547 | 0.88 | DHODH (0.61) | DHODHEPHX2CYP2C9CYP2C19RAB9A | |
| SCHEMBL9017605 | 0.88 | DHODH (0.61) | DHODHEPHX2RAB9AMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0533573-B1 | Derivatives of 3-cyclo alkyl-propen-2-amide, their tautomeres and salts and their use as antiinflammatory agents | ROUSSEL UCLAF (FR) | 1996-12-04 | — | — | EP | claimed |
| US-5312830-A | Antiinflammatory agents | ROUSSEL-UCLAF (FR) | 1994-05-17 | — | — | US | claimed |
| EP-0533573-A2 | Derivatives of 3-cyclo alkyl-propen-2-amide, their tautomeres and salts and their use as antiinflammatory agents | ROUSSEL UCLAF (FR) | 1993-03-24 | — | — | EP | claimed |
| EP-0533573-B1 | Derivatives of 3-cyclo alkyl-propen-2-amide, their tautomeres and salts and their use as antiinflammatory agents | ROUSSEL UCLAF (FR) | 1996-12-04 | — | — | EP | disclosed |
| US-5389652-A | Antiinflammatory agent | ROUSSEL-UCLAF (FR) | 1995-02-14 | — | — | US | disclosed |
| US-5312830-A | Antiinflammatory agents | ROUSSEL-UCLAF (FR) | 1994-05-17 | — | — | US | disclosed |
| EP-0533573-A2 | Derivatives of 3-cyclo alkyl-propen-2-amide, their tautomeres and salts and their use as antiinflammatory agents | ROUSSEL UCLAF (FR) | 1993-03-24 | — | — | EP | disclosed |