Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 14/20 | 0.66 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | BRAF | P15056 | 2/20 | 0.40 |
| ▸ | RAF1 | P04049 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1704272 | 0.92 | KARS1 (0.74) | KARS1DYRK1ABRAFRAF1 | |
| SCHEMBL901421 | 0.90 | KARS1 (0.82) | KARS1DYRK1A | |
| SCHEMBL901791 | 0.89 | KARS1 (0.81) | KARS1DYRK1ABRAFRAF1 | |
| SCHEMBL1704905 | 0.89 | KARS1 (0.83) | KARS1RXFP1 | |
| SCHEMBL901889 | 0.88 | KARS1 (0.81) | KARS1 | |
| SCHEMBL1705215 | 0.88 | KARS1 (0.62) | KARS1SYK | |
| SCHEMBL902036 | 0.88 | KARS1 (0.81) | KARS1DYRK1A | |
| SCHEMBL902079 | 0.88 | KARS1 (0.70) | KARS1DYRK1ABRAFRAF1 | |
| SCHEMBL901833 | 0.88 | KARS1 (0.72) | KARS1DYRK1ABRAFRAF1 | |
| SCHEMBL902211 | 0.87 | KARS1 (0.58) | KARS1DYRK1ASYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |