Hypophosphorous Acid

Hypophosphorous Acid

SCHEMBL9017574

CCN(CC)CC.COc1ccc(C(OC[C@H]2O[C@@H](n3cnc4c(=O)[nH]c(NC(=O)Cc5ccc(Br)cc5)nc43)C[C@@H]2O)(c2ccccc2)c2ccc(OC)cc2)cc1.O=[PH2]O

nearest known ligand 0.50

Full drug profile on Sugi Atlas →

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
TYMP P19971 7/20 0.50
POLA1 P09884 1/20 0.42
POLB P06746 1/20 0.37
TAS1R3 Q7RTX0 1/20 0.37
TAS1R1 Q7RTX1 1/20 0.37
KDM4E B2RXH2 1/20 0.37
NT5E P21589 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.34
P2RY2 P41231 1/20 0.33
P2RY4 P51582 1/20 0.33
P2RY6 Q15077 1/20 0.33
ALDH1A1 P00352 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9017501 0.92 TYMP (0.58) TYMPPOLA1POLBTAS1R3TAS1R1
SCHEMBL9238078 0.91 TYMP (0.58) TYMPPOLA1POLBTAS1R3TAS1R1
SCHEMBL9017508 0.89 TYMP (0.55) TYMPPOLA1POLBTAS1R3TAS1R1
SCHEMBL9017505 0.86 TYMP (0.53) TYMPPOLA1POLBTAS1R3TAS1R1
SCHEMBL32677371 0.86 TYMP (0.58) TYMPPOLA1POLBTAS1R3TAS1R1
SCHEMBL31342955 0.84 TYMP (0.61) TYMPPOLA1POLBTAS1R3TAS1R1
SCHEMBL12714672 0.83 TYMP (0.59) TYMPPOLA1POLBTAS1R3TAS1R1
SCHEMBL21828784 0.83 TYMP (0.59) TYMPPOLA1POLBTAS1R3TAS1R1
SCHEMBL2281663 0.83 TYMP (0.59) TYMPPOLA1POLBTAS1R3TAS1R1
SCHEMBL31556051 0.83 TYMP (0.59) TYMPPOLA1POLBTAS1R3TAS1R1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0749436-A1 COMPOSITIONS AND METHODS FOR USE IN THE SYNTHESIS OF OLIGONUCLEOTIDES BECKMAN INSTRUMENTS, INC. (US) 1996-12-27 EP disclosed
WO-1995024413-A1 COMPOSITIONS AND METHODS FOR USE IN THE SYNTHESIS OF OLIGONUCLEOTIDES BECKMAN INSTRUMENTS, INC. (US) 1995-09-14 WO disclosed