SCHEMBL2281663

SCHEMBL2281663

COc1ccc(C(OC[C@H]2O[C@@H](n3cnc4c(=O)[nH]c(NC(=O)C(C)C)nc43)C[C@@H]2O)(c2ccccc2)c2ccc(OC)cc2)cc1

nearest known ligand 0.65

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
TYMP P19971 10/20 0.59
KDM4E B2RXH2 1/20 0.53
POLA1 P09884 1/20 0.45
TAS1R3 Q7RTX0 1/20 0.43
TAS1R1 Q7RTX1 1/20 0.43
POLB P06746 1/20 0.41
TYMS P04818 1/20 0.38
P2RY2 P41231 1/20 0.38
P2RY4 P51582 1/20 0.38
P2RY6 Q15077 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12714672 1.00 TYMP (0.59) TYMPKDM4EPOLA1TAS1R3TAS1R1
SCHEMBL3821714 1.00 TYMP (0.59) TYMPKDM4EPOLA1TAS1R3TAS1R1
SCHEMBL21828784 1.00 TYMP (0.59) TYMPKDM4EPOLA1TAS1R3TAS1R1
SCHEMBL31556051 1.00 TYMP (0.59) TYMPKDM4EPOLA1TAS1R3TAS1R1
SCHEMBL31093208 0.94 TYMP (0.51) TYMPKDM4EPOLA1TAS1R3TAS1R1
SCHEMBL29799112 0.93 KDM4E (0.52) TYMPKDM4EPOLA1TAS1R3TAS1R1
SCHEMBL3820892 0.92 KDM4E (0.56) TYMPKDM4EPOLA1TAS1R3TAS1R1
SCHEMBL31342955 0.92 TYMP (0.61) TYMPKDM4EPOLA1TAS1R3TAS1R1
SCHEMBL32677371 0.90 TYMP (0.58) TYMPKDM4EPOLA1TAS1R3TAS1R1
SCHEMBL9017501 0.90 TYMP (0.58) TYMPKDM4EPOLA1TAS1R3TAS1R1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 100 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107099004-B A kind of fluorescence hydrogel of high intensity and preparation method thereof 河南理工大学 2019-08-16 CN claimed
CN-107099004-A A kind of fluorescence hydrogel of high intensity and preparation method thereof 河南理工大学 2017-08-29 CN claimed
US-20260138999-A1 REAGENTS AND THEIR USE FOR MODULAR ENANTIODIVERGENT SYNTHESIS OF C-P BONDS BRISTOL MYERS SQUIBB CO (US) 2026-05-21 US disclosed
EP-4741411-A2 OLIGONUCLEOTIDE PRODUCTION METHOD, AND NUCLEOSIDE, NUCLEOTIDE, OR OLIGONUCLEOTIDE AJINOMOTO CO., INC. (JP) 2026-05-13 EP disclosed
US-12559517-B2 Oligonucleotide manufacturing method AJINOMOTO CO., INC. (JP) 2026-02-24 US disclosed
US-12492217-B2 Reagents and their use for modular enantiodivergent synthesis of C—P bonds BRISTOL-MYERS SQUIBB COMPANY (US) 2025-12-09 US disclosed
EP-4640693-A1 METHOD FOR PRODUCING PRODUCTION INTERMEDIATE, PRODUCTION INTERMEDIATE THEREOF, AND METHOD FOR PRODUCING CROSSLINKED ARTIFICIAL NUCLEIC ACID INTERMEDIATE BY USING SAME Mitsubishi Tanabe Pharma Corporation (JP) 2025-10-29 EP disclosed
US-20250313591-A1 METHOD FOR PRODUCING PRODUCTION INTERMEDIATE, PRODUCTION INTERMEDIATE THEREOF, AND METHOD FOR PRODUCING CROSSLINKED ARTIFICIAL NUCLEIC ACID INTERMEDIATE BY USING SAME MITSUBISHI TANABE PHARMA CORPORATION (JP) 2025-10-09 US disclosed
US-12415835-B2 Peptide-compound cyclization method CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2025-09-16 US disclosed
US-12337291-B2 Guide RNA synthesis system and method SYNTHEGO CORPORATION (US) 2025-06-24 US disclosed
US-12269841-B2 Production method for oligonucleotides AJINOMOTO CO., INC. (JP) 2025-04-08 US disclosed
US-5132418-A On modified silica support UNIVERSITY PATENTS, INC. (US) 1992-07-21 US disclosed
EP-0035719-B1 PROCESS FOR PRODUCING MODIFIED INORGANIC POLYMERS, THEIR USE IN PRODUCING POLYNUCLEOTIDES, AND A REAGENT USEFUL IN THESE PROCESSES UNIVERSITY PATENTS, INC. (US) 1989-09-20 EP disclosed
US-4835263-A Novel compounds containing an oligonucleotide sequence bonded to an intercalating agent, a process for their synthesis and their use CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) 1989-05-30 US disclosed
EP-0117777-B1 COMPOUNDS CONTAINING AN OLIGONUCLEOTIDE BONDED TO AN INTERCALLATING AGENT, A PROCESS FOR THEIR PREPARATION AND THEIR APPLICATION Etablissement Public dit: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) 1987-12-23 EP disclosed
US-4500707-A Nucleosides useful in the preparation of polynucleotides UNIVERSITY PATENTS, INC. (US) 1985-02-19 US disclosed
EP-0102995-A1 POLYNUCLEOTIDE SYNTHESIS CELLTECH LIMITED (GB) 1984-03-21 EP disclosed
EP-0097805-A2 Nucleoside phosphite compounds UNIVERSITY PATENTS, INC. (US) 1984-01-11 EP disclosed
WO-1983003098-A1 POLYNUCLEOTIDE SYNTHESIS EATON, MICHAEL, ANTHONY, WILLIAM 1983-09-15 WO disclosed
EP-0035719-A2 Process for producing modified inorganic polymers, their use in producing polynucleotides, and a reagent useful in these processes UNIVERSITY PATENTS, INC. (US) 1981-09-16 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260138999-A1 REAGENTS AND THEIR USE FOR MODULAR ENANTIODIVERGENT SYNTHESIS OF C-P BONDS RNGTT, CDA, DCTD TYMP 80/4885KDM4E 3277/4885POLA1 49/4885
US-20250313591-A1 METHOD FOR PRODUCING PRODUCTION INTERMEDIATE, PRODUCTION INTERMEDIATE THEREOF, AND METHOD FOR PRODUCING CROSSLINKED ARTIFICIAL NUCLEIC ACID INTERMEDIATE BY USING SAME POLRMT, COASY, RNGTT TYMP 152/4885KDM4E 2781/4885POLA1 77/4885
US-12559517-B2 Oligonucleotide manufacturing method POLL, IGF2BP1, POLI TYMP 149/4885KDM4E 3231/4885POLA1 31/4885
US-12415835-B2 Peptide-compound cyclization method VIP, NGLY1, GLP1R TYMP 2728/4885KDM4E 4623/4885POLA1 4570/4885
US-12492217-B2 Reagents and their use for modular enantiodivergent synthesis of C—P bonds PNKP, POLL, RNGTT TYMP 51/4885KDM4E 3574/4885POLA1 138/4885
US-12269841-B2 Production method for oligonucleotides RNGTT, DCLRE1B, PHOSPHO1 TYMP 30/4885KDM4E 2580/4885POLA1 37/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.