Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | NAAA | Q02083 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | FAAH | O00519 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9017925 | 1.00 | MAPT (0.35) | MAPTLMNAHTTALDH1A1CNR1 | |
| Dimethylcarbate SCHEMBL9681187 | 0.92 | MAPT (0.36) | MAPTLMNAHTTALDH1A1POLB | |
| Dimethylcarbate SCHEMBL9681182 | 0.92 | MAPT (0.36) | MAPTLMNAHTTALDH1A1POLB | |
| SCHEMBL9679870 | 0.89 | — | — | |
| SCHEMBL9017876 | 0.83 | MAPT (0.32) | MAPTLMNAHTTALDH1A1TDP1 | |
| SCHEMBL9017915 | 0.82 | NPSR1 (0.39) | MAPTCNR1CNR2 | |
| SCHEMBL9017902 | 0.82 | NPSR1 (0.39) | MAPTCNR1CNR2 | |
| Dimethylcarbate SCHEMBL9680344 | 0.81 | KDM6B (0.34) | — | |
| SCHEMBL9017921 | 0.78 | MAPT (0.37) | MAPTLMNAHTTALDH1A1POLB | |
| SCHEMBL9017850 | 0.76 | ALDH1A1 (0.35) | MAPTHTTALDH1A1L3MBTL1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0477903-B1 | Substituted-4-amino-3-pyridinols, a process for their preparation and their use as medicaments | HOECHST ROUSSEL PHARMA (US) | 1996-04-03 | — | — | EP | disclosed |
| EP-0477903-A2 | Substituted-4-amino-3-pyridinols, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-04-01 | — | — | EP | disclosed |