Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 17/20 | 1.00 |
| ▸ | PRKD1 | Q15139 | 3/20 | 0.42 |
| ▸ | PRKD2 | Q9BZL6 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL901800 | 0.88 | KARS1 (0.78) | KARS1 | |
| SCHEMBL901852 | 0.84 | KARS1 (0.77) | KARS1PRKD1PRKD2 | |
| SCHEMBL1755643 | 0.83 | KARS1 (1.00) | KARS1PRKD1PRKD2 | |
| SCHEMBL901269 | 0.83 | KARS1 (0.70) | KARS1PRKD1PRKD2 | |
| SCHEMBL901889 | 0.82 | KARS1 (0.81) | KARS1PRKD1PRKD2 | |
| SCHEMBL1755684 | 0.81 | KARS1 (0.78) | KARS1PRKD1PRKD2 | |
| SCHEMBL1755690 | 0.80 | KARS1 (0.73) | KARS1PRKD1PRKD2 | |
| SCHEMBL901927 | 0.80 | KARS1 (0.73) | KARS1PRKD1PRKD2 | |
| SCHEMBL902410 | 0.80 | KARS1 (0.81) | KARS1PRKD1PRKD2 | |
| SCHEMBL1755644 | 0.79 | KARS1 (0.76) | KARS1PRKD1PRKD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |