Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 16/20 | 0.78 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | MGLL | Q99685 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL901799 | 0.88 | KARS1 (1.00) | KARS1 | |
| SCHEMBL902211 | 0.85 | KARS1 (0.58) | KARS1SYKDYRK1A | |
| SCHEMBL1704693 | 0.85 | KARS1 (0.59) | KARS1 | |
| SCHEMBL1704272 | 0.85 | KARS1 (0.74) | KARS1DYRK1A | |
| SCHEMBL901757 | 0.84 | KARS1 (0.66) | KARS1SYKDYRK1A | |
| SCHEMBL902091 | 0.83 | KARS1 (0.58) | KARS1SYK | |
| SCHEMBL901988 | 0.83 | KARS1 (0.55) | KARS1DYRK1A | |
| SCHEMBL901439 | 0.83 | KARS1 (0.55) | KARS1SYKDYRK1A | |
| SCHEMBL901857 | 0.82 | KARS1 (0.57) | KARS1DYRK1A | |
| SCHEMBL901752 | 0.81 | KARS1 (0.73) | KARS1DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |