Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2L1 | Q07817 | 8/20 | 0.40 |
| ▸ | BCL2 | P10415 | 7/20 | 0.40 |
| ▸ | P4HTM | Q9NXG6 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.38 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9018366 | 0.93 | P4HTM (0.37) | BCL2L1BCL2P4HTMALDH1A1HPGD | |
| SCHEMBL9018102 | 0.92 | BCL2L1 (0.38) | BCL2L1BCL2P4HTMALDH1A1HPGD | |
| SCHEMBL9018144 | 0.92 | BCL2L1 (0.39) | BCL2L1BCL2P4HTMALDH1A1HPGD | |
| SCHEMBL9018259 | 0.90 | LIMK1 (0.45) | BCL2L1BCL2P4HTMHDAC1HDAC6 | |
| SCHEMBL7867702 | 0.88 | BCL2L1 (0.37) | BCL2L1BCL2P4HTMALDH1A1HPGD | |
| SCHEMBL7862880 | 0.87 | P4HTM (0.37) | BCL2L1BCL2P4HTMALDH1A1HPGD | |
| SCHEMBL9018092 | 0.85 | SMN1; SMN2 (0.47) | BCL2L1P4HTMALDH1A1MCL1MEN1 | |
| SCHEMBL9140272 | 0.85 | P4HTM (0.47) | BCL2L1BCL2P4HTMALDH1A1HPGD | |
| SCHEMBL9018042 | 0.84 | SMN1; SMN2 (0.43) | BCL2L1P4HTMHDAC6MCL1MEN1 | |
| SCHEMBL9517927 | 0.83 | P4HTM (0.42) | BCL2L1BCL2P4HTMALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0590520-B1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AG (DE) | 1996-06-12 | — | — | EP | disclosed |
| EP-0590520-A1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-04-06 | — | — | EP | disclosed |