Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.48 |
| ▸ | SGMS1 | Q86VZ5 | 5/20 | 0.46 |
| ▸ | BCL2L1 | Q07817 | 3/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9018028 | 0.92 | PTPN1 (0.53) | POLBPTPN1SGMS1BCL2L1MCL1 | |
| SCHEMBL9018226 | 0.90 | CA1 (0.48) | ALDH1A1LMNAMAPTOPRM1OPRD1 | |
| SCHEMBL9018051 | 0.90 | ALDH1A1 (0.45) | POLBALDH1A1LMNAGAAMAPT | |
| SCHEMBL9018298 | 0.90 | PTPN1 (0.55) | POLBPTPN1SGMS1BCL2L1MCL1 | |
| SCHEMBL9018484 | 0.90 | POLB (0.49) | POLBPTPN1SGMS1BCL2L1MCL1 | |
| SCHEMBL9018186 | 0.89 | POLB (0.51) | POLBPTPN1SGMS1BCL2L1MCL1 | |
| SCHEMBL9018251 | 0.89 | MAPT (0.49) | BCL2L1MCL1LMNAMAPTOPRM1 | |
| SCHEMBL9018212 | 0.89 | POLB (0.49) | POLBPTPN1SGMS1BCL2L1MCL1 | |
| SCHEMBL9018140 | 0.89 | POLB (0.49) | POLBPTPN1SGMS1BCL2L1MCL1 | |
| SCHEMBL9018429 | 0.88 | NPC1 (0.51) | POLBLMNAMAPTOPRM1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0590520-B1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AG (DE) | 1996-06-12 | — | — | EP | disclosed |
| EP-0590520-A1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-04-06 | — | — | EP | disclosed |