Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | SGMS1 | Q86VZ5 | 6/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | BCL2L1 | Q07817 | 3/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9018186 | 0.93 | POLB (0.51) | PTPN1POLBSGMS1ALDH1A1BCL2L1 | |
| SCHEMBL9018015 | 0.92 | POLB (0.49) | PTPN1POLBSGMS1ALDH1A1BCL2L1 | |
| SCHEMBL9018484 | 0.92 | POLB (0.49) | PTPN1POLBSGMS1ALDH1A1BCL2L1 | |
| SCHEMBL9018096 | 0.92 | PTPN1 (0.47) | PTPN1POLBSGMS1ALDH1A1LMNA | |
| SCHEMBL9018212 | 0.91 | POLB (0.49) | PTPN1POLBSGMS1ALDH1A1BCL2L1 | |
| SCHEMBL9018140 | 0.91 | POLB (0.49) | PTPN1POLBSGMS1ALDH1A1BCL2L1 | |
| SCHEMBL9018298 | 0.90 | PTPN1 (0.55) | PTPN1POLBSGMS1ALDH1A1BCL2L1 | |
| SCHEMBL7870440 | 0.90 | PTPN1 (0.49) | PTPN1POLBSGMS1ALDH1A1BCL2L1 | |
| SCHEMBL9018302 | 0.89 | CA1 (0.50) | SGMS1ALDH1A1BCL2L1MCL1SMN1; SMN2 | |
| SCHEMBL9018029 | 0.88 | MEN1 (0.50) | ALDH1A1BCL2L1MCL1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0590520-B1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AG (DE) | 1996-06-12 | — | — | EP | disclosed |
| EP-0590520-A1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-04-06 | — | — | EP | disclosed |