Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | EGFR | P00533 | 2/20 | 0.42 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.41 |
| ▸ | CA12 | O43570 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | CA9 | Q16790 | 2/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9018251 | 0.91 | MAPT (0.49) | MEN1KMT2ALMNATP53SMN1; SMN2 | |
| SCHEMBL9018200 | 0.91 | ALDH1A1 (0.48) | ACACBPOLBMEN1KMT2ALMNA | |
| SCHEMBL9017987 | 0.91 | CA1 (0.41) | ACACBLMNATP53ALDH1A1SMN1; SMN2 | |
| SCHEMBL9017979 | 0.90 | PPARA (0.50) | MEN1KMT2ALMNATP53SMN1; SMN2 | |
| SCHEMBL9018324 | 0.90 | MAPT (0.54) | POLBMEN1KMT2ALMNATP53 | |
| SCHEMBL9018220 | 0.90 | PPARA (0.50) | MEN1KMT2ALMNATP53SMN1; SMN2 | |
| SCHEMBL9018414 | 0.90 | MAPT (0.54) | POLBMEN1KMT2ALMNATP53 | |
| SCHEMBL9018429 | 0.90 | NPC1 (0.51) | POLBMEN1KMT2ALMNATP53 | |
| SCHEMBL9018260 | 0.89 | KMT2A (0.54) | MEN1KMT2ALMNATP53ALDH1A1 | |
| SCHEMBL9018451 | 0.89 | HSD17B10 (0.50) | KMT2ALMNATP53ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0590520-B1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AG (DE) | 1996-06-12 | — | — | EP | disclosed |
| EP-0590520-A1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-04-06 | — | — | EP | disclosed |