Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.39 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | STS | P08842 | 2/20 | 0.36 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9018372 | 0.92 | LMNA (0.44) | LMNACYP3A4HTR1AMAPTCYP2C9 | |
| SCHEMBL9018253 | 0.89 | LMNA (0.44) | LMNACYP3A4HTR1AMAPTCYP2C9 | |
| SCHEMBL9018292 | 0.89 | HSD17B10 (0.48) | SMN1; SMN2HSD17B10ALDH1A1POLBCNR2 | |
| SCHEMBL9018153 | 0.87 | LMNA (0.42) | LMNACYP3A4HTR1AMAPTCYP2C9 | |
| SCHEMBL9018388 | 0.86 | LMNA (0.41) | LMNACYP3A4HTR1AMAPTCYP2C9 | |
| SCHEMBL9018401 | 0.86 | ALDH1A1 (0.41) | LMNAHSD17B10ALDH1A1POLBCNR2 | |
| SCHEMBL9018030 | 0.85 | LMNA (0.39) | LMNACYP3A4HTR1AMAPTCYP2C9 | |
| SCHEMBL9018267 | 0.84 | HSD17B10 (0.45) | LMNACYP3A4HTR1AMAPTCYP2C9 | |
| SCHEMBL9018170 | 0.84 | LMNA (0.46) | LMNACYP3A4HTR1AMAPTCYP2C9 | |
| SCHEMBL9018433 | 0.84 | CTDSP1 (0.41) | LMNASMN1; SMN2HSD17B10ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0590520-B1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AG (DE) | 1996-06-12 | — | — | EP | disclosed |
| EP-0590520-A1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-04-06 | — | — | EP | disclosed |