Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 4/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.53 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.53 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.53 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | CFTR | P13569 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | HTR2A | P28223 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | PPARG | P37231 | 1/20 | 0.53 |
| ▸ | HTR2B | P41595 | 1/20 | 0.53 |
| ▸ | BLM | P54132 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9018449 | 1.00 | NLRP3 (0.60) | NLRP3MEN1ABCC3ABCC4ABCC9 | |
| SCHEMBL9018044 | 0.93 | NLRP3 (0.61) | NLRP3MEN1ABCC3ABCC4ABCC9 | |
| SCHEMBL9018124 | 0.93 | NLRP3 (0.62) | NLRP3MEN1ABCC3ABCC4ABCC9 | |
| SCHEMBL9018196 | 0.93 | NLRP3 (0.67) | NLRP3MEN1ABCC3ABCC4ABCC9 | |
| SCHEMBL9018228 | 0.90 | NLRP3 (0.63) | NLRP3MEN1ABCC3ABCC4ABCC9 | |
| SCHEMBL9017982 | 0.89 | PPARA (0.47) | NLRP3MEN1ALDH1A1LMNACYP1A2 | |
| SCHEMBL9018306 | 0.89 | PPARA (0.47) | NLRP3MEN1ALDH1A1LMNACYP1A2 | |
| SCHEMBL9018248 | 0.87 | NLRP3 (0.52) | NLRP3MEN1ABCC3ABCC4ABCC9 | |
| SCHEMBL9018156 | 0.87 | ALDH1A1 (0.46) | NLRP3MEN1ALDH1A1LMNAMAPT | |
| SCHEMBL9018111 | 0.87 | ALDH1A1 (0.46) | NLRP3MEN1ALDH1A1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0590520-B1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AG (DE) | 1996-06-12 | — | — | EP | disclosed |
| EP-0590520-A1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-04-06 | — | — | EP | disclosed |