Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.41 |
| ▸ | P4HTM | Q9NXG6 | 4/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.37 |
| ▸ | FLT1 | P17948 | 1/20 | 0.37 |
| ▸ | FLT4 | P35916 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9018203 | 0.92 | EGFR (0.42) | EGFRP4HTMCA12CA9OPRM1 | |
| SCHEMBL9018422 | 0.92 | CA2 (0.41) | EGFRP4HTMOPRK1EPHX2 | |
| SCHEMBL9018397 | 0.91 | P4HTM (0.41) | EGFRP4HTMEPHX2GABRA5 | |
| SCHEMBL9018082 | 0.90 | CA2 (0.47) | EGFRP4HTMOPRK1EPHX2 | |
| SCHEMBL9018309 | 0.89 | SCN3A (0.46) | P4HTMCA12CA9OPRM1OPRD1 | |
| SCHEMBL9018299 | 0.89 | EPHX2 (0.38) | EGFRP4HTMEPHX2 | |
| SCHEMBL9018479 | 0.89 | EGFR (0.43) | EGFRP4HTMCA12CA9OPRM1 | |
| SCHEMBL9018004 | 0.89 | P4HTM (0.48) | EGFRP4HTMCA12CA9OPRM1 | |
| SCHEMBL9018513 | 0.89 | NPC1 (0.47) | P4HTMCA9OPRM1OPRD1OPRK1 | |
| SCHEMBL9018283 | 0.88 | KMT2A (0.43) | EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0590520-B1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AG (DE) | 1996-06-12 | — | — | EP | disclosed |
| EP-0590520-A1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-04-06 | — | — | EP | disclosed |