Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P4HTM | Q9NXG6 | 3/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.39 |
| ▸ | EGFR | P00533 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9018299 | 0.93 | EPHX2 (0.38) | P4HTMEPHX2EGFRKMT2AHPGD | |
| SCHEMBL9018422 | 0.92 | CA2 (0.41) | P4HTMEPHX2EGFRKMT2AKDM4E | |
| SCHEMBL9018307 | 0.91 | EGFR (0.41) | P4HTMEPHX2GABRA5EGFR | |
| SCHEMBL9018310 | 0.91 | RAB9A (0.48) | P4HTMKMT2AHPGDALDH1A1MEN1 | |
| SCHEMBL9018082 | 0.90 | CA2 (0.47) | P4HTMEPHX2EGFRKMT2AALDH1A1 | |
| SCHEMBL9018283 | 0.90 | KMT2A (0.43) | EPHX2KMT2AHPGDKDM4EALDH1A1 | |
| SCHEMBL9018202 | 0.89 | P4HTM (0.43) | P4HTMEPHX2GABRA5EGFRKMT2A | |
| SCHEMBL9018513 | 0.89 | NPC1 (0.47) | P4HTMKMT2AMEN1 | |
| SCHEMBL9018090 | 0.88 | KMT2A (0.50) | P4HTMKMT2AALDH1A1MEN1 | |
| SCHEMBL9018091 | 0.88 | MEN1 (0.44) | P4HTMKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0590520-B1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AG (DE) | 1996-06-12 | — | — | EP | disclosed |
| EP-0590520-A1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-04-06 | — | — | EP | disclosed |