Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.53 |
| ▸ | PPARA | Q07869 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | FLT1 | P17948 | 1/20 | 0.49 |
| ▸ | FLT4 | P35916 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.49 |
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9018127 | 0.93 | PPARA (0.49) | EGFRPPARAMEN1KMT2AFLT1 | |
| SCHEMBL9018339 | 0.93 | PPARA (0.49) | EGFRPPARAMEN1KMT2AFLT1 | |
| SCHEMBL9018220 | 0.92 | PPARA (0.50) | EGFRPPARAMEN1KMT2AFLT1 | |
| SCHEMBL9017979 | 0.92 | PPARA (0.50) | EGFRPPARAMEN1KMT2AFLT1 | |
| SCHEMBL9018029 | 0.91 | MEN1 (0.50) | PPARAMEN1KMT2AMAPTNPC1 | |
| SCHEMBL9017988 | 0.91 | PPARA (0.48) | EGFRPPARAMEN1KMT2AFLT1 | |
| SCHEMBL9018230 | 0.91 | PPARA (0.48) | EGFRPPARAMEN1KMT2AFLT1 | |
| SCHEMBL9018049 | 0.91 | MAPT (0.54) | MEN1KMT2AMAPTNPC1CYP2C19 | |
| SCHEMBL9018057 | 0.91 | KMT2A (0.58) | PPARAMEN1KMT2AMAPTNPC1 | |
| SCHEMBL9018181 | 0.91 | MAPT (0.54) | MEN1KMT2AMAPTNPC1CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0590520-B1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AG (DE) | 1996-06-12 | — | — | EP | disclosed |
| EP-0590520-A1 | Acylsulphonamido and sulphonamidopyridine-2-carboxylic acid esters, pyridine-n-oxides thereof, a process for their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-04-06 | — | — | EP | disclosed |