Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Alanine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.50 |
| ▸ | SLC7A5 | Q01650 | 2/20 | 0.48 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | FYN | P06241 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.37 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.37 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.37 |
| ▸ | LTA4H | P09960 | 1/20 | 0.37 |
| ▸ | GABRP | O00591 | 4/20 | 0.36 |
| ▸ | GABRD | O14764 | 4/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 4/20 | 0.36 |
| ▸ | GABRB1 | P18505 | 4/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 4/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 4/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 4/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Alanine SCHEMBL28317985 | 0.97 | LMNA (0.53) | LMNAALOX15BLMPMP22SLC7A5 | |
| Alanine SCHEMBL17873222 | 0.97 | LMNA (0.53) | LMNAALOX15BLMPMP22SLC7A5 | |
| Alanine SCHEMBL17873220 | 0.94 | LMNA (0.50) | LMNAALOX15BLMPMP22SLC7A5 | |
| D-Alanine SCHEMBL1314451 | 0.94 | SLC7A5 (0.53) | SLC7A5FFAR3LCKFYNTP53 | |
| D-Alanine SCHEMBL31494467 | 0.94 | SLC7A5 (0.53) | SLC7A5FFAR3LCKFYNTP53 | |
| Alanine SCHEMBL468681 | 0.94 | SLC7A5 (0.53) | SLC7A5FFAR3LCKFYNTP53 | |
| Alanine SCHEMBL28538824 | 0.94 | SLC7A5 (0.53) | SLC7A5FFAR3LCKFYNTP53 | |
| Alanine SCHEMBL468682 | 0.94 | SLC7A5 (0.53) | SLC7A5FFAR3LCKFYNTP53 | |
| Alanine SCHEMBL6160098 | 0.94 | SLC7A5 (0.53) | SLC7A5FFAR3LCKFYNTP53 | |
| Alanine SCHEMBL6160093 | 0.94 | SLC7A5 (0.53) | SLC7A5FFAR3LCKFYNTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5550015-A | PRECIPITATING A SILVERBROMOIODIDE CORE BY DOUBLE JET METHOD; RIPENING; GROWING GRAINS BY ADDING SILVER IONS FROM ONE SOLUTION AND BROMIDE AND IODIDE IONS FROM ANOTHER | AGFA-GEVAERT AG (DE) | 1996-08-27 | — | — | US | disclosed |