Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 6/20 | 0.66 |
| ▸ | HTR1A | P08908 | 1/20 | 0.56 |
| ▸ | HTR7 | P34969 | 1/20 | 0.56 |
| ▸ | OPRL1 | P41146 | 5/20 | 0.55 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.55 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.49 |
| ▸ | HTR1D | P28221 | 2/20 | 0.49 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9947164 | 1.00 | GRIN2B (0.66) | GRIN2BHTR1AHTR7OPRL1OPRM1 | |
| SCHEMBL9506641 | 1.00 | GRIN2B (0.66) | GRIN2BHTR1AHTR7OPRL1OPRM1 | |
| SCHEMBL7436031 | 1.00 | GRIN2B (0.66) | GRIN2BHTR1AHTR7OPRL1OPRM1 | |
| Hydrochloric Acid SCHEMBL7938970 | 0.98 | GRIN2B (0.64) | GRIN2BHTR1AHTR7OPRL1OPRM1 | |
| SCHEMBL9947176 | 0.98 | GRIN2B (0.68) | GRIN2BHTR1AHTR7OPRL1OPRM1 | |
| SCHEMBL8673995 | 0.98 | GRIN2B (0.68) | GRIN2BHTR1AHTR7OPRL1OPRM1 | |
| SCHEMBL9727205 | 0.94 | GRIN2B (0.68) | GRIN2BHTR1AHTR7OPRL1OPRM1 | |
| SCHEMBL13468211 | 0.90 | GRIN2B (0.62) | GRIN2BHTR1AHTR7OPRL1OPRM1 | |
| SCHEMBL12670642 | 0.88 | GRIN2B (0.65) | GRIN2BHTR1AHTR7OPRL1OPRM1 | |
| SCHEMBL11620522 | 0.86 | FYN (0.59) | GRIN2BHTR1AHTR7TSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5545755-A | USEFUL TO TREAT CENTRAL NERVOUS SYSTEM DISORDERS, HYPERTENSION, DIABETES, SEXUAL IMPOTENCY AND TO CONTROL APPETITE | THE UPJOHN COMPANY (US) | 1996-08-13 | — | — | US | disclosed |
| EP-0552246-A1 | THERAPEUTICALLY USEFUL 2-AMINOTETRALIN DERIVATIVES | PHARMACIA & UPJOHN COMPANY (US) | 1993-07-28 | — | — | EP | disclosed |
| WO-1992006967-A1 | THERAPEUTICALLY USEFUL 2-AMINOTETRALIN DERIVATIVES | THE UPJOHN COMPANY (US) | 1992-04-30 | — | — | WO | disclosed |