Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 7/20 | 0.68 |
| ▸ | OPRL1 | P41146 | 5/20 | 0.56 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.56 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.56 |
| ▸ | HTR1A | P08908 | 1/20 | 0.54 |
| ▸ | HTR7 | P34969 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.50 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9947176 | 0.96 | GRIN2B (0.68) | GRIN2BOPRL1OPRM1OPRK1HTR1A | |
| SCHEMBL8673995 | 0.96 | GRIN2B (0.68) | GRIN2BOPRL1OPRM1OPRK1HTR1A | |
| SCHEMBL9506641 | 0.94 | GRIN2B (0.66) | GRIN2BOPRL1OPRM1OPRK1HTR1A | |
| SCHEMBL7436031 | 0.94 | GRIN2B (0.66) | GRIN2BOPRL1OPRM1OPRK1HTR1A | |
| SCHEMBL9947164 | 0.94 | GRIN2B (0.66) | GRIN2BOPRL1OPRM1OPRK1HTR1A | |
| SCHEMBL9018525 | 0.94 | GRIN2B (0.66) | GRIN2BOPRL1OPRM1OPRK1HTR1A | |
| Hydrochloric Acid SCHEMBL7938970 | 0.93 | GRIN2B (0.64) | GRIN2BOPRL1OPRM1OPRK1HTR1A | |
| SCHEMBL4486847 | 0.87 | CHRNA7 (0.59) | GRIN2BOPRL1OPRM1OPRK1HTR1A | |
| SCHEMBL12670642 | 0.86 | GRIN2B (0.65) | GRIN2BOPRL1OPRM1OPRK1HTR1A | |
| SCHEMBL9345993 | 0.85 | GRIN2B (0.56) | GRIN2BOPRL1OPRM1OPRK1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5164385-A | AZETIDINE DERIVATIVES AND HYPOTENSIVE COMPOSITIONS THEREOF | JOHN WYETH & BROTHER, LTD. (GB) | 1992-11-17 | — | — | US | claimed |
| US-5164385-A | AZETIDINE DERIVATIVES AND HYPOTENSIVE COMPOSITIONS THEREOF | JOHN WYETH & BROTHER, LTD. (GB) | 1992-11-17 | — | — | US | disclosed |