Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 6/20 | 0.53 |
| ▸ | SYK | P43405 | 10/20 | 0.46 |
| ▸ | IDH2 | P48735 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | BRAF | P15056 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL901253 | 0.90 | KARS1 (0.65) | KARS1MAPK8MAPK10 | |
| SCHEMBL1704640 | 0.88 | KARS1 (0.56) | KARS1SYKIDH2MEN1TSHR | |
| SCHEMBL1704871 | 0.88 | KARS1 (0.44) | KARS1SYKIDH2 | |
| SCHEMBL901977 | 0.83 | KARS1 (0.65) | KARS1SYKIDH2MAPK8MAPK10 | |
| SCHEMBL1704085 | 0.83 | SYK (0.49) | KARS1SYK | |
| SCHEMBL1705099 | 0.82 | KARS1 (0.47) | KARS1SYKIDH2 | |
| SCHEMBL1704896 | 0.82 | KARS1 (0.60) | KARS1MAPK8MAPK10 | |
| SCHEMBL902653 | 0.81 | KARS1 (0.80) | KARS1SYKBRAF | |
| SCHEMBL1704569 | 0.80 | SYK (0.46) | KARS1SYK | |
| SCHEMBL1704571 | 0.80 | SYK (0.46) | KARS1SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |