Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 13/20 | 0.65 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 2/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.38 |
| ▸ | BCR | P11274 | 2/20 | 0.38 |
| ▸ | SRC | P12931 | 2/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.38 |
| ▸ | PRKCA | P17252 | 2/20 | 0.38 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.38 |
| ▸ | BUB1 | O43683 | 1/20 | 0.37 |
| ▸ | TYK2 | P29597 | 2/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | WNT1 | P04628 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.36 |
| ▸ | PRKCG | P05129 | 1/20 | 0.36 |
| ▸ | PRKCB | P05771 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL901867 | 0.90 | KARS1 (0.53) | KARS1MAPK8MAPK10 | |
| SCHEMBL1704896 | 0.90 | KARS1 (0.60) | KARS1MAPK8MAPK10ABL1PDGFRB | |
| SCHEMBL902062 | 0.89 | KARS1 (0.57) | KARS1TYK2JAK2JAK1WNT1 | |
| SCHEMBL1704276 | 0.87 | KARS1 (0.68) | KARS1MAPK8MAPK10ABL1PDGFRB | |
| SCHEMBL12469310 | 0.84 | KARS1 (0.56) | KARS1TYK2 | |
| SCHEMBL1704520 | 0.83 | KARS1 (0.60) | KARS1MAPK8TYK2JAK1WNT1 | |
| SCHEMBL902036 | 0.82 | KARS1 (0.81) | KARS1MAPK8MAPK10ABL1PDGFRB | |
| SCHEMBL1705351 | 0.81 | KARS1 (0.52) | KARS1MAPK8TYK2JAK1WNT1 | |
| SCHEMBL901888 | 0.80 | KARS1 (0.68) | KARS1TYK2JAK2JAK1WNT1 | |
| SCHEMBL901742 | 0.79 | KARS1 (1.00) | KARS1MAPK8MAPK10PRKD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |