Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 11/20 | 0.52 |
| ▸ | BRAF | P15056 | 2/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | TYK2 | P29597 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12469132 | 0.85 | KARS1 (0.72) | KARS1MEN1KMT2AJAK2NPC1 | |
| SCHEMBL901754 | 0.83 | KARS1 (0.58) | KARS1JAK2JAK1TYK2NPC1 | |
| SCHEMBL902093 | 0.82 | TP53 (0.41) | BRAFHIF1AMEN1KMT2ASIRT2 | |
| SCHEMBL902681 | 0.82 | KARS1 (0.70) | KARS1MEN1KMT2A | |
| SCHEMBL901917 | 0.82 | KARS1 (0.53) | KARS1 | |
| SCHEMBL902605 | 0.82 | KARS1 (0.56) | KARS1NPC1RAB9A | |
| SCHEMBL901722 | 0.82 | KARS1 (0.52) | KARS1SIRT2JAK2JAK1TYK2 | |
| SCHEMBL1705304 | 0.81 | KARS1 (0.47) | KARS1BRAFSIRT2 | |
| SCHEMBL901844 | 0.79 | KARS1 (0.52) | KARS1HIF1AMEN1KMT2A | |
| SCHEMBL901364 | 0.78 | KARS1 (0.48) | KARS1SIRT2JAK2JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |