Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 8/20 | 0.52 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.39 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | TACR3 | P29371 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | RIOK2 | Q9BVS4 | 1/20 | 0.37 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1704064 | 0.85 | KARS1 (0.69) | KARS1ROCK2ROCK1SLC5A1 | |
| SCHEMBL12469132 | 0.85 | KARS1 (0.72) | KARS1MAPTMEN1KMT2A | |
| SCHEMBL1704269 | 0.84 | KARS1 (0.47) | KARS1ROCK2ROCK1SLC5A1RIOK2 | |
| SCHEMBL902605 | 0.81 | KARS1 (0.56) | KARS1 | |
| SCHEMBL901917 | 0.80 | KARS1 (0.53) | KARS1 | |
| SCHEMBL901872 | 0.79 | KARS1 (0.52) | KARS1HIF1AMEN1KMT2A | |
| SCHEMBL901894 | 0.73 | KARS1 (0.71) | KARS1MAPTMEN1KMT2A | |
| SCHEMBL902891 | 0.73 | KARS1 (0.45) | KARS1HPGDSLC5A1MAPT | |
| SCHEMBL1705223 | 0.72 | KARS1 (0.47) | KARS1 | |
| SCHEMBL10268805 | 0.72 | KARS1 (0.69) | KARS1IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |