Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR1 | Q9Y271 | 10/20 | 0.61 |
| ▸ | CYSLTR2 | Q9NS75 | 8/20 | 0.61 |
| ▸ | GPBAR1 | Q8TDU6 | 5/20 | 0.61 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | GMNN | O75496 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.58 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8666312 | 0.87 | CYSLTR1 (0.72) | CYSLTR1CYSLTR2GPBAR1ALOX5MAPK1 | |
| SCHEMBL29426330 | 0.83 | CYSLTR1 (0.78) | CYSLTR1CYSLTR2GPBAR1ALOX5MAPK1 | |
| SCHEMBL10544630 | 0.83 | CYSLTR1 (0.84) | CYSLTR1CYSLTR2GPBAR1ALOX5MAPK1 | |
| SCHEMBL9018916 | 0.82 | ALOX5 (0.67) | CYSLTR1CYSLTR2GPBAR1ALOX5MAPK1 | |
| SCHEMBL10411470 | 0.81 | ALOX5 (0.66) | CYSLTR1CYSLTR2GPBAR1ALOX5MAPK1 | |
| SCHEMBL10410383 | 0.80 | CYSLTR2 (0.62) | CYSLTR1CYSLTR2GPBAR1ALOX5MAPK1 | |
| SCHEMBL10411468 | 0.80 | ALOX5 (0.62) | CYSLTR1CYSLTR2GPBAR1ALOX5MAPK1 | |
| SCHEMBL10410457 | 0.80 | ALOX5 (0.62) | CYSLTR1CYSLTR2GPBAR1ALOX5MAPK1 | |
| SCHEMBL8715478 | 0.79 | CYSLTR1 (0.61) | CYSLTR1CYSLTR2GPBAR1ALOX5MAPK1 | |
| SCHEMBL9498315 | 0.79 | ALOX5 (0.63) | CYSLTR1CYSLTR2GPBAR1ALOX5MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0414019-B1 | Subsituted N-(quinolin-2-yl-methoxy)benzylsulfonylureas | BAYER AG (DE) | 1996-05-29 | — | — | EP | disclosed |
| US-5179106-A | SUBSTITUTED N-(QUINOLIN-2-YL-METHOXY) BENZYL-SULPHONYLUREA LEUKOTRIENE SYNTHESIS INHIBITORS | BAYER AKTIENGESELLSCHAFT (DE) | 1993-01-12 | — | — | US | disclosed |
| EP-0414019-A2 | Subsituted N-(quinolin-2-yl-methoxy)benzylsulfonylureas | BAYER AG (DE) | 1991-02-27 | — | — | EP | disclosed |