⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9019014 | 1.00 | — | — | |
| SCHEMBL9019018 | 1.00 | — | — | |
| SCHEMBL8775764 | 0.80 | THRB (0.33) | — | |
| SCHEMBL8127935 | 0.79 | — | — | |
| SCHEMBL28910125 | 0.77 | — | — | |
| SCHEMBL27335392 | 0.77 | — | — | |
| SCHEMBL224974 | 0.76 | — | — | |
| SCHEMBL9075927 | 0.74 | — | — | |
| SCHEMBL2944079 | 0.74 | — | — | |
| SCHEMBL2941165 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115043895-A | PNU-159682 and preparation method of intermediate thereof | 戊言医药科技（上海）有限公司 | 2022-09-13 | — | — | CN | claimed |
| CN-119912476-A | Preparation method of PNU-159582 | 上海皓元生物医药科技有限公司 | 2025-05-02 | — | — | CN | disclosed |
| CN-119912511-A | Intermediate of PNU-159582 and preparation method thereof | 上海皓元生物医药科技有限公司 | 2025-05-02 | — | — | CN | disclosed |
| CN-115043895-A | PNU-159682 and preparation method of intermediate thereof | 戊言医药科技（上海）有限公司 | 2022-09-13 | — | — | CN | disclosed |
| EP-0434960-B1 | Chiral 1,5-diiodo-2-methoxy or benzyloxy intermediates | PHARMACIA SPA (IT) | 1996-09-18 | — | — | EP | disclosed |
| US-5304687-A | 1-alkoxy-2,2*-diiodo-diethyl ether which reacts with doxorubicin to yield anthrocycline antibiotics | FARMITALIA CARLO ERBA S.R.L. (IT) | 1994-04-19 | — | — | US | disclosed |
| EP-0434960-A1 | Chiral 1,5-diiodo-2-methoxy or benzyloxy intermediates | PHARMACIA S.p.A. (IT) | 1991-07-03 | — | — | EP | disclosed |
| WO-1991009046-A1 | MORPHOLINYL DERIVATIVES OF DOXORUBICIN AND PROCESS FOR THEIR PREPARATION | FARMITALIA CARLO ERBA S.R.L. (IT) | 1991-06-27 | — | — | WO | disclosed |