Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 13/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.48 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SYK | P43405 | 1/20 | 0.44 |
| ▸ | PRKACA | P17612 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1704400 | 0.91 | KARS1 (0.63) | KARS1CYP3A4ROCK1HTTSYK | |
| SCHEMBL901829 | 0.91 | KARS1 (0.81) | KARS1CYP3A4ROCK1HTT | |
| SCHEMBL901834 | 0.90 | KARS1 (0.82) | KARS1SYK | |
| SCHEMBL901656 | 0.88 | KARS1 (0.63) | KARS1 | |
| SCHEMBL901935 | 0.85 | KARS1 (0.65) | KARS1 | |
| SCHEMBL901973 | 0.85 | KARS1 (0.69) | KARS1MAPTSYK | |
| SCHEMBL902144 | 0.84 | KARS1 (0.59) | KARS1SYK | |
| SCHEMBL902224 | 0.84 | KARS1 (0.55) | KARS1 | |
| SCHEMBL901757 | 0.84 | KARS1 (0.66) | KARS1SYK | |
| SCHEMBL1704964 | 0.82 | KARS1 (0.74) | KARS1SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |