Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXA2R | P21731 | 13/20 | 0.51 |
| ▸ | TBXAS1 | P24557 | 8/20 | 0.45 |
| ▸ | PTGDR | Q13258 | 2/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | PDE2A | O00408 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.38 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.38 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9019676 | 0.95 | TBXA2R (0.47) | TBXA2RTBXAS1HDAC3HDAC1HDAC10 | |
| SCHEMBL9019726 | 0.91 | TBXA2R (0.52) | TBXA2RTBXAS1PTGDR2 | |
| SCHEMBL9019713 | 0.90 | TBXA2R (0.53) | TBXA2RTBXAS1PTGDRHDAC3HDAC1 | |
| SCHEMBL9019678 | 0.89 | TBXA2R (0.42) | TBXA2RTBXAS1HDAC3HDAC1HDAC10 | |
| SCHEMBL9019682 | 0.88 | TBXA2R (0.52) | TBXA2RPTGDRPDE2APTGDR2HRH3 | |
| SCHEMBL9019680 | 0.85 | TBXA2R (0.72) | TBXA2RTBXAS1PTGDRPDE2A | |
| SCHEMBL9019686 | 0.85 | TBXA2R (0.48) | TBXA2RTBXAS1HDAC3HDAC1HDAC10 | |
| SCHEMBL9019712 | 0.85 | TBXA2R (0.53) | TBXA2RTBXAS1PTGDR2 | |
| SCHEMBL10412691 | 0.84 | TBXA2R (0.70) | TBXA2RTBXAS1PTGDRPDE2APTGDR2 | |
| SCHEMBL9019718 | 0.84 | TBXA2R (0.69) | TBXA2RTBXAS1PTGDRPDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0496237-B1 | N-imidazolyl derivatives of substituted tetrahydrocarbazole and cyclohept[b]indole | PHARMACIA SPA (IT) | 1996-02-14 | — | — | EP | claimed |
| EP-0496237-A2 | N-imidazolyl derivatives of substituted tetrahydrocarbazole and cyclohept[b]indole | PHARMACIA S.p.A. (IT) | 1992-07-29 | — | — | EP | claimed |
| EP-0496237-B1 | N-imidazolyl derivatives of substituted tetrahydrocarbazole and cyclohept[b]indole | PHARMACIA SPA (IT) | 1996-02-14 | — | — | EP | disclosed |
| US-5238953-A | Thromboxane a2 antagonist | FARMITALIA CARLO ERBA S.R.L. (IT) | 1993-08-24 | — | — | US | disclosed |
| EP-0496237-A2 | N-imidazolyl derivatives of substituted tetrahydrocarbazole and cyclohept[b]indole | PHARMACIA S.p.A. (IT) | 1992-07-29 | — | — | EP | disclosed |