Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 13/20 | 0.35 |
| ▸ | NR3C1 | P04150 | 8/20 | 0.34 |
| ▸ | AR | P10275 | 7/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.32 |
| ▸ | STS | P08842 | 1/20 | 0.32 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9019862 | 0.89 | PGR (0.38) | PGRNR3C1ARCYP3A4CYP1B1 | |
| SCHEMBL8639950 | 0.89 | PGR (0.35) | PGRNR3C1ARCYP3A4CYP1B1 | |
| SCHEMBL8541047 | 0.85 | PGR (0.48) | PGRNR3C1ARCYP3A4 | |
| SCHEMBL9019894 | 0.81 | CYP1B1 (0.47) | PGRCYP1B1CYP17A1 | |
| SCHEMBL9019871 | 0.80 | CYP1B1 (0.47) | PGRCYP1B1CYP17A1 | |
| SCHEMBL8768109 | 0.75 | PGR (0.47) | PGRNR3C1ARCYP3A4 | |
| SCHEMBL8536387 | 0.75 | PGR (0.51) | PGRNR3C1ARCYP3A4 | |
| SCHEMBL8536181 | 0.75 | PGR (0.49) | PGRNR3C1ARCYP3A4 | |
| SCHEMBL8587938 | 0.74 | PDK1 (0.41) | PGRNR3C1ARCYP3A4 | |
| SCHEMBL8537287 | 0.74 | PDK1 (0.41) | PGRNR3C1ARCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0404283-B1 | 11-Beta-aryl-4-estrene, method for its production and its use as a medicine | SCHERING AG (DE) | 1996-05-08 | — | — | EP | disclosed |
| EP-0404283-A2 | 11-Beta-aryl-4-estrene, method for its production and its use as a medicine | SCHERING AKTIENGESELLSCHAFT (DE) | 1990-12-27 | — | — | EP | disclosed |