Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 14/20 | 0.62 |
| ▸ | PGR | P06401 | 14/20 | 0.62 |
| ▸ | AR | P10275 | 10/20 | 0.62 |
| ▸ | CYP2C8 | P10632 | 2/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9019846 | 0.85 | NR3C1 (0.83) | NR3C1PGRARCYP2C8CYP3A4 | |
| SCHEMBL7643246 | 0.80 | PGR (0.48) | NR3C1PGRARCYP2C8CYP3A4 | |
| SCHEMBL10949515 | 0.79 | PGR (0.51) | NR3C1PGRARCYP2C8CYP3A4 | |
| SCHEMBL20048408 | 0.77 | NR3C1 (0.81) | NR3C1PGRARCYP2C8CYP3A4 | |
| SCHEMBL9019843 | 0.77 | PGR (0.42) | NR3C1PGRARCYP3A4CYP2C9 | |
| SCHEMBL19042673 | 0.76 | NR3C1 (1.00) | NR3C1PGRARCYP2C8CYP3A4 | |
| SCHEMBL19042656 | 0.75 | NR3C1 (0.68) | NR3C1PGRARCYP2C8CYP3A4 | |
| SCHEMBL21729781 | 0.75 | NR3C1 (0.68) | NR3C1PGRARCYP2C8CYP3A4 | |
| SCHEMBL9019877 | 0.75 | PGR (0.46) | NR3C1PGRARCYP3A4 | |
| SCHEMBL20048202 | 0.74 | NR3C1 (0.55) | NR3C1PGRARCYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0404283-B1 | 11-Beta-aryl-4-estrene, method for its production and its use as a medicine | SCHERING AG (DE) | 1996-05-08 | — | — | EP | claimed |