Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B1 | P14061 | 2/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA5A | P35218 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 13/20 | 0.36 |
| ▸ | PGR | P06401 | 4/20 | 0.34 |
| ▸ | AR | P10275 | 3/20 | 0.34 |
| ▸ | STS | P08842 | 2/20 | 0.34 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | SHBG | P04278 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | SERPINA6 | P08185 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20048420 | 0.89 | PGR (0.45) | HSD17B1CYP19A1PGRARSTS | |
| SCHEMBL20048421 | 0.89 | PGR (0.45) | HSD17B1CYP19A1PGRARSTS | |
| SCHEMBL10449168 | 0.88 | CYP19A1 (0.36) | HSD17B1CYP19A1PGRARSTS | |
| SCHEMBL10448763 | 0.87 | PGR (0.45) | HSD17B1CYP19A1PGRARSTS | |
| SCHEMBL8540866 | 0.86 | CYP19A1 (0.35) | HSD17B1CYP19A1PGRARSTS | |
| SCHEMBL21470228 | 0.84 | PGR (0.46) | HSD17B1CA1CA2CA9CYP19A1 | |
| SCHEMBL9019871 | 0.82 | CYP1B1 (0.47) | CYP19A1PGRCYP1B1 | |
| SCHEMBL8539498 | 0.82 | PDK1 (0.37) | CYP19A1PGRARSTSAKR1B10 | |
| SCHEMBL21729696 | 0.74 | PGR (0.43) | PGRARCYP3A4NR3C1 | |
| SCHEMBL9177360 | 0.73 | POLB (0.46) | HSD17B1CA1CA2CA5ACA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0404283-B1 | 11-Beta-aryl-4-estrene, method for its production and its use as a medicine | SCHERING AG (DE) | 1996-05-08 | — | — | EP | disclosed |
| EP-0404283-A2 | 11-Beta-aryl-4-estrene, method for its production and its use as a medicine | SCHERING AKTIENGESELLSCHAFT (DE) | 1990-12-27 | — | — | EP | disclosed |