Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPRT1 | P00492 | 6/20 | 0.57 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.55 |
| ▸ | PNP | P00491 | 3/20 | 0.54 |
| ▸ | TK1 | P04183 | 2/20 | 0.51 |
| ▸ | BLM | P54132 | 2/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | EDNRA | P25101 | 1/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | HBB | P68871 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | VCP | P55072 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9019958 | 1.00 | HPRT1 (0.57) | HPRT1ADORA3PNPTK1BLM | |
| SCHEMBL23721010 | 0.92 | HPRT1 (0.55) | HPRT1ADORA3PNPTK1BLM | |
| SCHEMBL10394261 | 0.92 | HPRT1 (0.55) | HPRT1ADORA3PNPTK1BLM | |
| SCHEMBL9309680 | 0.91 | HPRT1 (0.58) | HPRT1ADORA3PNPTK1BLM | |
| SCHEMBL6538609 | 0.86 | HPRT1 (0.56) | HPRT1ADORA3PNPTK1BLM | |
| SCHEMBL1981358 | 0.86 | HPRT1 (0.56) | HPRT1ADORA3PNPTK1BLM | |
| SCHEMBL30150327 | 0.86 | HPRT1 (0.56) | HPRT1ADORA3PNPTK1BLM | |
| SCHEMBL1981357 | 0.86 | HPRT1 (0.56) | HPRT1ADORA3PNPTK1BLM | |
| SCHEMBL21050282 | 0.86 | HPRT1 (0.56) | HPRT1ADORA3PNPTK1BLM | |
| SCHEMBL9471250 | 0.86 | PNP (0.57) | HPRT1ADORA3PNPTK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0352013-B1 | Hydroxymethyl cyclobutyl purines | SQUIBB & SONS INC (US) | 1996-05-01 | — | — | EP | claimed |
| US-5369098-A | Viricides | E. R. SQUIBB & SONS, INC. (US) | 1994-11-29 | — | — | US | claimed |
| EP-0352013-A2 | Hydroxymethyl cyclobutyl purines | E.R. Squibb & Sons, Inc. (US) | 1990-01-24 | — | — | EP | claimed |
| JP-2073072-A | — | — | None | — | — | JP | disclosed |
| US-12202850-B2 | Cyclobutyl purine derivative or salt thereof | FUJIFILM CORPORATION (JP) | 2025-01-21 | — | — | US | disclosed |
| EP-3831388-B1 | CYCLOPENTENYL PURINE DERIVATIVE OR SALT THEREOF FOR USE IN SUPPRESSING ADENOVIRUS | FUJIFILM CORP (JP) | 2024-02-28 | — | — | EP | disclosed |
| US-20230295202-A1 | CYCLOBUTYL PURINE DERIVATIVE OR SALT THEREOF | FUJIFILM CORPORATION (JP) | 2023-09-21 | — | — | US | disclosed |
| EP-3831836-B1 | CYCLOBUTYL PURINE DERIVATIVE OR SALT THEREOF | FUJIFILM CORP (JP) | 2023-09-06 | — | — | EP | disclosed |
| EP-3831388-A1 | CYCLOPENTENYL PURINE DERIVATIVE OR SALT THEREOF | FUJIFILM Corporation (JP) | 2021-06-09 | — | — | EP | disclosed |
| EP-3831836-A1 | CYCLOBUTYL PURINE DERIVATIVE OR SALT THEREOF | FUJIFILM Corporation (JP) | 2021-06-09 | — | — | EP | disclosed |
| US-20210155644-A1 | CYCLOPENTENYL PURINE DERIVATIVE OR SALT THEREOF | FUJIFILM CORPORATION (JP) | 2021-05-27 | — | — | US | disclosed |
| WO-2020022487-A1 | CYCLOBUTYL PURINE DERIVATIVE OR SALT THEREOF | 富士フイルム株式会社 | 2020-01-30 | — | — | WO | disclosed |
| EP-0352013-B1 | Hydroxymethyl cyclobutyl purines | SQUIBB & SONS INC (US) | 1996-05-01 | — | — | EP | disclosed |
| US-5369098-A | Viricides | E. R. SQUIBB & SONS, INC. (US) | 1994-11-29 | — | — | US | disclosed |
| US-5246931-A | Triazine-substituted cyclobutane derivatives; viricides; side effect reduction | BRISTOL-MYERS SQUIBB COMPANY (US) | 1993-09-21 | — | — | US | disclosed |
| US-5153352-A | Viricides and antitumor agent | BRISTOL-MYERS SQUIBB COMPANY (US) | 1992-10-06 | — | — | US | disclosed |
| EP-0366059-A2 | Carbocyclic nucleoside analogs | BRISTOL-MYERS SQUIBB COMPANY (US) | 1990-05-02 | — | — | EP | disclosed |
| JP-H0273072-A | HYDROXYMETHYL CYCLOBUTYL PURINE | E R SQUIBB & SONS INC | 1990-03-13 | — | — | JP | disclosed |
| EP-0352013-A2 | Hydroxymethyl cyclobutyl purines | E.R. Squibb & Sons, Inc. (US) | 1990-01-24 | — | — | EP | disclosed |
| EP-0330992-A2 | Novel cyclobutane Derivatives, processes for their preparation and pharmaceutical compositions comprising them | Nippon Kayaku Kabushiki Kaisha (JP) | 1989-09-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230295202-A1 | CYCLOBUTYL PURINE DERIVATIVE OR SALT THEREOF | SLC28A1, SLC20A1, SLC29A1 | HPRT1 24/4885ADORA3 14/4885PNP 48/4885 |
| US-12202850-B2 | Cyclobutyl purine derivative or salt thereof | SLC28A1, SLC20A1, SLC29A1 | HPRT1 24/4885ADORA3 14/4885PNP 48/4885 |
| US-20210155644-A1 | CYCLOPENTENYL PURINE DERIVATIVE OR SALT THEREOF | SLC28A1, SLC20A1, NOX1 | HPRT1 143/4885ADORA3 94/4885PNP 103/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.