SCHEMBL902012

SCHEMBL902012

CNC(=O)OC1CCCN1Cc1ccccc1-c1ccc2nc(N)nc(C(=O)N3Cc4ccccc4C3)c2c1

nearest known ligand 0.62

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 11/20 0.62
HSP90AB1 P08238 3/20 0.47
CYP1A2 P05177 1/20 0.32
F10 P00742 1/20 0.31
KDM4E B2RXH2 2/20 0.31
HTT P42858 2/20 0.31
NPSR1 Q6W5P4 2/20 0.31
MAPT P10636 1/20 0.31
GPR55 Q9Y2T6 1/20 0.31
PDCD1 Q15116 1/20 0.31
CD274 Q9NZQ7 1/20 0.31
ALOX5AP P20292 2/20 0.30
FEN1 P39748 2/20 0.30
PADI4 Q9UM07 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL902115 0.92 HSP90AA1 (0.62) HSP90AA1HSP90AB1F10KDM4EHTT
SCHEMBL901443 0.92 HSP90AA1 (0.66) HSP90AA1HSP90AB1CYP1A2F10KDM4E
SCHEMBL901807 0.91 HSP90AA1 (0.61) HSP90AA1HSP90AB1CYP1A2F10
SCHEMBL10256124 0.87 HSP90AA1 (0.64) HSP90AA1HSP90AB1CYP1A2PDCD1CD274
SCHEMBL904223 0.86 HSP90AA1 (0.69) HSP90AA1HSP90AB1KDM4ECD274
SCHEMBL904034 0.86 HSP90AA1 (0.69) HSP90AA1HSP90AB1KDM4ECD274
SCHEMBL904226 0.86 HSP90AA1 (0.69) HSP90AA1HSP90AB1KDM4ECD274
SCHEMBL903946 0.86 HSP90AA1 (0.64) HSP90AA1HSP90AB1PDCD1CD274
SCHEMBL904181 0.85 HSP90AA1 (0.69) HSP90AA1HSP90AB1CYP1A2PDCD1CD274
SCHEMBL904169 0.84 HSP90AA1 (0.71) HSP90AA1HSP90AB1F10KDM4EPDCD1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2621919-A1 PHENYLQUINAZOLINE DERIVATIVES Merck Patent GmbH (DE) 2013-08-07 EP claimed
WO-2012041435-A1 PHENYLQUINAZOLINE DERIVATIVES MERCK PATENT GMBH (DE) 2012-04-05 WO claimed
EP-2621919-A1 PHENYLQUINAZOLINE DERIVATIVES Merck Patent GmbH (DE) 2013-08-07 EP disclosed
WO-2012041435-A1 PHENYLQUINAZOLINE DERIVATIVES MERCK PATENT GMBH (DE) 2012-04-05 WO disclosed