Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | CDK8 | P49336 | 1/20 | 0.44 |
| ▸ | IDH2 | P48735 | 1/20 | 0.41 |
| ▸ | RIOK2 | Q9BVS4 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 7/20 | 0.40 |
| ▸ | GPR52 | Q9Y2T5 | 3/20 | 0.40 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1704065 | 0.86 | KARS1 (0.48) | IDH2RIOK2SYKNR3C2AURKA | |
| SCHEMBL901986 | 0.85 | SYK (0.50) | IDH2SYK | |
| SCHEMBL1704715 | 0.84 | IDH2 (0.40) | CA12CA1CA2CA9IDH2 | |
| SCHEMBL902093 | 0.84 | TP53 (0.41) | TRPV1RAB9ATP53 | |
| SCHEMBL901917 | 0.84 | KARS1 (0.53) | CDK8IDH2SYKGPR52NR3C2 | |
| SCHEMBL902605 | 0.75 | KARS1 (0.56) | RAB9ASYK | |
| SCHEMBL1704561 | 0.71 | KARS1 (0.55) | IDH2SYK | |
| SCHEMBL12469132 | 0.70 | KARS1 (0.72) | RAB9ASYKNR3C2 | |
| SCHEMBL901724 | 0.70 | KARS1 (0.57) | IDH2SYK | |
| SCHEMBL4536310 | 0.70 | CNR1 (0.62) | TRPV1NR3C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |