Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 4/20 | 0.48 |
| ▸ | SYK | P43405 | 5/20 | 0.45 |
| ▸ | IDH2 | P48735 | 1/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.43 |
| ▸ | PRKCH | P24723 | 1/20 | 0.40 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.40 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | RIOK2 | Q9BVS4 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.38 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL902028 | 0.86 | CA12 (0.45) | SYKIDH2NR3C2AURKARIOK2 | |
| SCHEMBL1704561 | 0.82 | KARS1 (0.55) | KARS1SYKIDH2TAAR1 | |
| SCHEMBL1704715 | 0.82 | IDH2 (0.40) | SYKIDH2NR3C2AURKARIOK2 | |
| SCHEMBL1704403 | 0.82 | KARS1 (0.47) | KARS1SYKPRKCHPRKCEROCK1 | |
| SCHEMBL902073 | 0.82 | KARS1 (0.71) | KARS1SYKIDH2TAAR1NR3C2 | |
| SCHEMBL901984 | 0.73 | IDH2 (0.42) | KARS1SYKIDH2AURKARIOK2 | |
| SCHEMBL902820 | 0.72 | KARS1 (0.74) | KARS1SYKIDH2 | |
| SCHEMBL902026 | 0.71 | TAAR1 (0.45) | KARS1SYKTAAR1MAOBROCK1 | |
| SCHEMBL901986 | 0.69 | SYK (0.50) | KARS1SYKIDH2 | |
| SCHEMBL901883 | 0.67 | AURKA (0.56) | KARS1SYKIDH2NR3C2AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | claimed |
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |