Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | RAB9A | P51151 | 5/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1407148 | 0.84 | NPC1 (0.61) | NPC1LMNAALDH1A1RAB9AHPGD | |
| SCHEMBL7105351 | 0.81 | NPC1 (0.64) | NPC1LMNAALDH1A1RAB9AHPGD | |
| SCHEMBL9020337 | 0.80 | CYP3A4 (0.51) | NPC1LMNAALDH1A1RAB9AHPGD | |
| SCHEMBL1406952 | 0.80 | NPC1 (0.56) | NPC1LMNAALDH1A1RAB9AHPGD | |
| SCHEMBL173434 | 0.80 | NPC1 (0.68) | NPC1LMNAALDH1A1RAB9AHPGD | |
| SCHEMBL1406981 | 0.80 | NPC1 (0.58) | NPC1LMNAALDH1A1RAB9AHPGD | |
| SCHEMBL13766811 | 0.79 | CYP3A4 (0.41) | NPC1LMNAALDH1A1RAB9AHPGD | |
| SCHEMBL8234400 | 0.78 | TSHR (0.43) | LMNAALDH1A1KDM4ETSHRSMN1; SMN2 | |
| SCHEMBL24452557 | 0.77 | NPC1 (0.65) | NPC1LMNAALDH1A1RAB9AHPGD | |
| SCHEMBL18740310 | 0.76 | MAPK1 (0.54) | LMNAALDH1A1HPGDKMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0332156-B1 | Cephem compounds and processes for preparation thereof | FUJISAWA PHARMACEUTICAL CO (JP) | 1996-12-18 | — | — | EP | disclosed |
| US-5366970-A | Cephem compounds and pharmaceutically acceptable salts thereof | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-11-22 | — | — | US | disclosed |
| US-5173485-A | Bactericides, microbiocides | FUJISAWA PHARMACEUTICAL COMPANY, LTD. (JP) | 1992-12-22 | — | — | US | disclosed |
| EP-0332156-A2 | Cephem compounds and processes for preparation thereof | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1989-09-13 | — | — | EP | disclosed |