Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.40 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.38 |
| ▸ | MTOR | P42345 | 5/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | APAF1 | O14727 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL896991 | 0.80 | KMT2A (0.56) | KMT2ANPSR1HRH4PIK3CAMAP3K12 | |
| SCHEMBL9003193 | 0.69 | KMT2A (0.76) | KMT2ANPSR1HRH4PIK3CAMAP3K12 | |
| SCHEMBL13326955 | 0.66 | KMT2A (1.00) | KMT2ANPSR1HRH4PIK3CAMAP3K12 | |
| SCHEMBL9640988 | 0.65 | KMT2A (0.69) | KMT2ANPSR1HRH4PIK3CAMAP3K12 | |
| SCHEMBL9640164 | 0.65 | KMT2A (0.69) | KMT2ANPSR1HRH4PIK3CAMAP3K12 | |
| SCHEMBL9639621 | 0.64 | KMT2A (0.67) | KMT2ANPSR1HRH4PIK3CAMAP3K12 | |
| SCHEMBL10169024 | 0.64 | KMT2A (0.33) | KMT2AKDM4EALDH1A1MEN1GAA | |
| SCHEMBL3289509 | 0.63 | KMT2A (0.65) | KMT2ANPSR1HRH4PIK3CAMAP3K12 | |
| SCHEMBL9069830 | 0.63 | CASP1 (0.71) | KMT2ANPSR1HRH4PIK3CAMAP3K12 | |
| SCHEMBL855348 | 0.63 | MAPT (0.68) | KMT2ANPSR1HRH4PIK3CAMAP3K12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012044727-A2 | MANUFACTURING PROCESS FOR PYRIMIDINE DERIVATIVES | NOVARTIS AG (CH) | 2012-04-05 | — | — | WO | disclosed |