SCHEMBL9021510

SCHEMBL9021510

CCOC(=O)CN1C2CCCC1CC(NC(=O)c1cc(Cl)c(N)cc1OC)C2

nearest known ligand 0.70

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
DRD2 P14416 1/20 0.70
HTR4 Q13639 7/20 0.65

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9021649 0.96 HTR4 (0.70) DRD2HTR4
SCHEMBL9021426 0.93 DRD2 (0.60) DRD2HTR4
SCHEMBL9021874 0.92 DRD2 (0.69) DRD2HTR4
SCHEMBL9021767 0.90 DRD2 (0.66) DRD2HTR4
SCHEMBL9022006 0.89 DRD2 (0.65) DRD2HTR4
SCHEMBL9021509 0.89 DRD2 (0.78) DRD2HTR4
SCHEMBL9022002 0.88 DRD2 (0.64) DRD2HTR4
SCHEMBL9021671 0.88 DRD2 (0.64) DRD2HTR4
Hydrochloric Acid SCHEMBL29438090 0.88 DRD2 (0.77) DRD2HTR4
Hydrochloric Acid SCHEMBL9021500 0.88 DRD2 (0.77) DRD2HTR4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0640601-B1 BENZAMIDE DERIVATIVE HOKURIKU PHARMACEUTICAL (JP) 1996-12-04 EP claimed
US-5395832-A Gastrointestinal disorders HOKURIKU SEIYAKU CO., LTD. (JP) 1995-03-07 US claimed
EP-0640601-A1 BENZAMIDE DERIVATIVE HOKURIKU SEIYAKU CO., LTD. (JP) 1995-03-01 EP claimed
EP-0640601-B1 BENZAMIDE DERIVATIVE HOKURIKU PHARMACEUTICAL (JP) 1996-12-04 EP disclosed
US-5500422-A FOR TREATING GASTROINTESTINAL DISEASES HOKURIKU SEIYAKU CO. LTD. (JP) 1996-03-19 US disclosed
US-5395832-A Gastrointestinal disorders HOKURIKU SEIYAKU CO., LTD. (JP) 1995-03-07 US disclosed
EP-0640601-A1 BENZAMIDE DERIVATIVE HOKURIKU SEIYAKU CO., LTD. (JP) 1995-03-01 EP disclosed