Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 8/20 | 0.68 |
| ▸ | HTR1D | P28221 | 6/20 | 0.68 |
| ▸ | GABRP | O00591 | 7/20 | 0.66 |
| ▸ | GABRD | O14764 | 7/20 | 0.66 |
| ▸ | GABRA1 | P14867 | 7/20 | 0.66 |
| ▸ | GABRB1 | P18505 | 7/20 | 0.66 |
| ▸ | GABRG2 | P18507 | 7/20 | 0.66 |
| ▸ | GABRB3 | P28472 | 7/20 | 0.66 |
| ▸ | GABRA5 | P31644 | 7/20 | 0.66 |
| ▸ | GABRA3 | P34903 | 7/20 | 0.66 |
| ▸ | GABRA2 | P47869 | 7/20 | 0.66 |
| ▸ | GABRB2 | P47870 | 7/20 | 0.66 |
| ▸ | GABRA4 | P48169 | 7/20 | 0.66 |
| ▸ | GABRE | P78334 | 7/20 | 0.66 |
| ▸ | GABRA6 | Q16445 | 7/20 | 0.66 |
| ▸ | GABRG1 | Q8N1C3 | 7/20 | 0.66 |
| ▸ | GABRG3 | Q99928 | 7/20 | 0.66 |
| ▸ | GABRQ | Q9UN88 | 7/20 | 0.66 |
| ▸ | HTR1A | P08908 | 2/20 | 0.64 |
| ▸ | HTR6 | P50406 | 5/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9077698 | 1.00 | HTR1B (0.68) | HTR1BHTR1DGABRPGABRDGABRA1 | |
| SCHEMBL7808656 | 0.87 | GABRP (0.65) | HTR1BHTR1DGABRPGABRDGABRA1 | |
| SCHEMBL1122820 | 0.83 | HTR1B (0.73) | HTR1BHTR1DGABRPGABRDGABRA1 | |
| SCHEMBL1122822 | 0.83 | HTR1B (0.73) | HTR1BHTR1DGABRPGABRDGABRA1 | |
| SCHEMBL1803906 | 0.83 | HTR1B (0.73) | HTR1BHTR1DGABRPGABRDGABRA1 | |
| SCHEMBL9117342 | 0.82 | HTR1D (0.53) | HTR1BHTR1DGABRPGABRDGABRA1 | |
| SCHEMBL7804051 | 0.82 | HTR1D (0.73) | HTR1BHTR1DHTR1A | |
| SCHEMBL7804070 | 0.81 | HTR1D (0.65) | HTR1BHTR1D | |
| SCHEMBL7804905 | 0.81 | HTR1D (0.65) | HTR1BHTR1D | |
| SCHEMBL8208343 | 0.81 | HTR1B (1.00) | HTR1BHTR1DGABRPGABRDGABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0741723-A1 | TRIAZOLE DERIVATIVES | MERCK SHARP & DOHME LTD. (GB) | 1996-11-13 | — | — | EP | claimed |
| WO-1995021167-A1 | TRIAZOLE DERIVATIVES | MERCK SHARP & DOHME LIMITED (GB) | 1995-08-10 | — | — | WO | claimed |
| EP-0741723-A1 | TRIAZOLE DERIVATIVES | MERCK SHARP & DOHME LTD. (GB) | 1996-11-13 | — | — | EP | disclosed |
| WO-1995021167-A1 | TRIAZOLE DERIVATIVES | MERCK SHARP & DOHME LIMITED (GB) | 1995-08-10 | — | — | WO | disclosed |