Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 19/20 | 0.75 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.72 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.67 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.67 |
| ▸ | USP2 | O75604 | 1/20 | 0.67 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.67 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.67 |
| ▸ | MLNR | O43193 | 1/20 | 0.67 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.67 |
| ▸ | HTR3B | O95264 | 1/20 | 0.67 |
| ▸ | HMGCR | P04035 | 1/20 | 0.67 |
| ▸ | HTR1A | P08908 | 1/20 | 0.67 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.67 |
| ▸ | DRD2 | P14416 | 1/20 | 0.67 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.67 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.67 |
| ▸ | DRD1 | P21728 | 1/20 | 0.67 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.67 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.67 |
| ▸ | HTR2A | P28223 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9021517 | 1.00 | HTR4 (0.75) | HTR4KCNH2CYP3A4CYP2D6USP2 | |
| SCHEMBL9021506 | 1.00 | HTR4 (0.75) | HTR4KCNH2CYP3A4CYP2D6USP2 | |
| SCHEMBL9021491 | 1.00 | HTR4 (0.75) | HTR4KCNH2CYP3A4CYP2D6USP2 | |
| SCHEMBL9022024 | 1.00 | HTR4 (0.75) | HTR4KCNH2CYP3A4CYP2D6USP2 | |
| SCHEMBL12669528 | 0.93 | HTR4 (0.75) | HTR4KCNH2CYP3A4CYP2D6USP2 | |
| SCHEMBL1905248 | 0.93 | HTR4 (0.75) | HTR4KCNH2CYP3A4CYP2D6USP2 | |
| SCHEMBL12669516 | 0.91 | HTR4 (0.81) | HTR4KCNH2CYP3A4CYP2D6USP2 | |
| SCHEMBL1897144 | 0.91 | HTR4 (0.81) | HTR4KCNH2CYP3A4CYP2D6USP2 | |
| SCHEMBL8054851 | 0.90 | HTR4 (0.77) | HTR4KCNH2 | |
| Water SCHEMBL9721589 | 0.90 | HTR4 (0.76) | HTR4KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0640601-B1 | BENZAMIDE DERIVATIVE | HOKURIKU PHARMACEUTICAL (JP) | 1996-12-04 | — | — | EP | disclosed |
| US-5500422-A | FOR TREATING GASTROINTESTINAL DISEASES | HOKURIKU SEIYAKU CO. LTD. (JP) | 1996-03-19 | — | — | US | disclosed |
| US-5395832-A | Gastrointestinal disorders | HOKURIKU SEIYAKU CO., LTD. (JP) | 1995-03-07 | — | — | US | disclosed |
| EP-0640601-A1 | BENZAMIDE DERIVATIVE | HOKURIKU SEIYAKU CO., LTD. (JP) | 1995-03-01 | — | — | EP | disclosed |