Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 6/20 | 0.42 |
| ▸ | EGFR | P00533 | 3/20 | 0.42 |
| ▸ | PIM2 | Q9P1W9 | 3/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.42 |
| ▸ | CDC7 | O00311 | 3/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.42 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.42 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.42 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.42 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.42 |
| ▸ | JAK2 | O60674 | 2/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.42 |
| ▸ | PAK4 | O96013 | 2/20 | 0.42 |
| ▸ | PRKCG | P05129 | 2/20 | 0.42 |
| ▸ | CDK1 | P06493 | 2/20 | 0.42 |
| ▸ | FES | P07332 | 2/20 | 0.42 |
| ▸ | CSF1R | P07333 | 2/20 | 0.42 |
| ▸ | ROS1 | P08922 | 2/20 | 0.42 |
| ▸ | FER | P16591 | 2/20 | 0.42 |
| ▸ | PRKACA | P17612 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL902281 | 1.00 | PIM1 (0.42) | PIM1EGFRPIM2MAPK8CDC7 | |
| SCHEMBL26604133 | 0.81 | CDC7 (0.54) | PIM1EGFRPIM2MAPK8CDC7 | |
| SCHEMBL7790533 | 0.81 | MEN1 (0.41) | PIM1EGFRPIM2CDK1INSR | |
| SCHEMBL26604152 | 0.76 | LCK (0.50) | PIM1EGFRPIM2MAPK8CDC7 | |
| SCHEMBL21997528 | 0.76 | S1PR2 (0.41) | CSNK2A1S1PR2 | |
| SCHEMBL901805 | 0.76 | PDGFRB (0.50) | GSK3BPDGFRADYRK1AS1PR2PDGFRB | |
| SCHEMBL901803 | 0.76 | PDGFRB (0.50) | GSK3BPDGFRADYRK1AS1PR2PDGFRB | |
| SCHEMBL22081785 | 0.75 | TP53 (0.40) | PIM1EGFRPIM2MAPK8CDK1 | |
| SCHEMBL935044 | 0.75 | CDC7 (0.46) | PIM1EGFRPIM2MAPK8CDC7 | |
| SCHEMBL7790017 | 0.73 | MAPK14 (0.37) | PIM1EGFRCDC7CDK1INSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |