Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 3/20 | 0.50 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | S1PR2 | O95136 | 2/20 | 0.41 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.41 |
| ▸ | BTK | Q06187 | 1/20 | 0.37 |
| ▸ | WNT1 | P04628 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | PRCP | P42785 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL901805 | 1.00 | PDGFRB (0.50) | PDGFRBPDGFRALMNASMN1; SMN2MEN1 | |
| SCHEMBL25153864 | 0.79 | LMNA (0.51) | PDGFRBPDGFRALMNASMN1; SMN2MEN1 | |
| SCHEMBL29248610 | 0.79 | LMNA (0.51) | PDGFRBPDGFRALMNASMN1; SMN2MEN1 | |
| SCHEMBL902281 | 0.76 | PIM1 (0.42) | PDGFRBPDGFRAS1PR2GSK3BDYRK1A | |
| SCHEMBL902280 | 0.76 | PIM1 (0.42) | PDGFRBPDGFRAS1PR2GSK3BDYRK1A | |
| SCHEMBL29248501 | 0.75 | LMNA (0.48) | PDGFRBPDGFRALMNASMN1; SMN2MEN1 | |
| SCHEMBL25153875 | 0.75 | LMNA (0.48) | PDGFRBPDGFRALMNASMN1; SMN2MEN1 | |
| SCHEMBL2405309 | 0.75 | ALDH1A1 (0.56) | PDGFRBPDGFRASMN1; SMN2MEN1KMT2A | |
| SCHEMBL2405311 | 0.75 | ALDH1A1 (0.56) | PDGFRBPDGFRASMN1; SMN2MEN1KMT2A | |
| SCHEMBL901398 | 0.75 | LMNA (0.50) | PDGFRBPDGFRALMNASMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |