Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 9/20 | 0.40 |
| ▸ | AGTR2 | P50052 | 9/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8841654 | 0.87 | AGTR1 (0.49) | AGTR1AGTR2 | |
| SCHEMBL9024058 | 0.87 | AGTR1 (0.40) | AGTR1AGTR2 | |
| SCHEMBL9023186 | 0.87 | AGTR1 (0.45) | AGTR1AGTR2 | |
| SCHEMBL9023492 | 0.86 | AGTR2 (0.39) | AGTR1AGTR2 | |
| SCHEMBL9023338 | 0.84 | AGTR1 (0.44) | AGTR1AGTR2 | |
| SCHEMBL9022794 | 0.84 | AGTR1 (0.47) | AGTR1AGTR2 | |
| SCHEMBL9023020 | 0.84 | AGTR1 (0.42) | AGTR1AGTR2 | |
| SCHEMBL9023746 | 0.84 | AGTR1 (0.43) | AGTR1AGTR2 | |
| SCHEMBL9023317 | 0.84 | AGTR1 (0.44) | AGTR1AGTR2 | |
| SCHEMBL9023586 | 0.84 | AGTR1 (0.43) | AGTR1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0508445-B1 | 1-Arylheteroarylalkyl substituted-1H-1,2,4-triazole compounds for treatment of circulatory disorders | SEARLE & CO (US) | 1996-06-12 | — | — | EP | claimed |
| EP-0619819-B1 | 1-ARYLHETEROARYLALKYL SUBSTITUTED-1H-1,2,4-TRIAZOLE COMPOUNDS FOR TREATMENT OF CIRCULATORY DISORDERS | SEARLE & CO (US) | 1996-06-12 | — | — | EP | claimed |