Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 8/20 | 0.76 |
| ▸ | SOAT1 | P35610 | 2/20 | 0.72 |
| ▸ | NPBWR1 | P48145 | 6/20 | 0.60 |
| ▸ | NPC1 | O15118 | 4/20 | 0.58 |
| ▸ | MAPT | P10636 | 4/20 | 0.58 |
| ▸ | RAB9A | P51151 | 4/20 | 0.58 |
| ▸ | CASP3 | P42574 | 2/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.58 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.58 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.58 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.58 |
| ▸ | MMP2 | P08253 | 1/20 | 0.58 |
| ▸ | MMP9 | P14780 | 1/20 | 0.58 |
| ▸ | MMP8 | P22894 | 1/20 | 0.58 |
| ▸ | MMP13 | P45452 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.54 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.54 |
| ▸ | RELA | Q04206 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL902547 | 0.84 | DGAT1 (0.78) | DGAT1SOAT1 | |
| SCHEMBL901002 | 0.82 | DGAT1 (0.74) | DGAT1SOAT1 | |
| SCHEMBL902462 | 0.81 | DGAT1 (0.73) | DGAT1SOAT1 | |
| SCHEMBL900620 | 0.79 | DGAT1 (0.56) | DGAT1SOAT1 | |
| SCHEMBL900619 | 0.79 | DGAT1 (0.56) | DGAT1SOAT1 | |
| SCHEMBL20982700 | 0.78 | NPC1 (0.94) | NPBWR1NPC1MAPTRAB9ACASP3 | |
| SCHEMBL10189562 | 0.78 | DGAT1 (0.57) | DGAT1SOAT1NPBWR1NPC1MAPT | |
| SCHEMBL3539037 | 0.77 | DGAT1 (0.48) | DGAT1SOAT1ALDH1A1KMT2A | |
| SCHEMBL3539040 | 0.77 | DGAT1 (0.48) | DGAT1SOAT1ALDH1A1KMT2A | |
| SCHEMBL20982761 | 0.77 | NPC1 (0.97) | NPBWR1NPC1MAPTRAB9ACASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012044567-A2 | IMIDAZOLE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2012-04-05 | — | — | WO | disclosed |