Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 15/20 | 0.74 |
| ▸ | SOAT1 | P35610 | 2/20 | 0.74 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.63 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.63 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.50 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.50 |
| ▸ | FASN | P49327 | 1/20 | 0.50 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.50 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL902748 | 0.85 | DGAT1 (0.55) | DGAT1SOAT1KCNH2ADORA2AFASN | |
| SCHEMBL902547 | 0.85 | DGAT1 (0.78) | DGAT1SOAT1KCNH2ADORA2A | |
| SCHEMBL10188914 | 0.83 | DGAT1 (0.69) | DGAT1SOAT1KCNH2ADORA2A | |
| SCHEMBL901150 | 0.82 | DGAT1 (0.53) | DGAT1SOAT1KCNH2ADORA2AFASN | |
| SCHEMBL902210 | 0.82 | PKN1 (0.60) | DGAT1SOAT1KCNH2ADORA2APKN1 | |
| SCHEMBL902462 | 0.82 | DGAT1 (0.73) | DGAT1SOAT1KCNH2ADORA2A | |
| SCHEMBL902304 | 0.82 | DGAT1 (0.76) | DGAT1SOAT1 | |
| SCHEMBL10189104 | 0.81 | DGAT1 (0.52) | DGAT1SOAT1KCNH2ADORA2AFASN | |
| SCHEMBL12474232 | 0.81 | PKN1 (0.58) | DGAT1SOAT1KCNH2ADORA2APKN1 | |
| SCHEMBL14971872 | 0.78 | DGAT1 (1.00) | DGAT1SOAT1KCNH2ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012044567-A2 | IMIDAZOLE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2012-04-05 | — | — | WO | disclosed |