Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 7/20 | 0.54 |
| ▸ | EDNRA | P25101 | 6/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | CCR2 | P41597 | 1/20 | 0.50 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.49 |
| ▸ | PPARG | P37231 | 2/20 | 0.47 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.46 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.46 |
| ▸ | YWHAH | Q04917 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8900846 | 0.80 | EDNRA (0.81) | EDNRBEDNRA | |
| SCHEMBL9023124 | 0.78 | EDNRA (0.42) | EDNRBEDNRAPPARGPLA2G2A | |
| SCHEMBL6858382 | 0.77 | PPARG (0.76) | EDNRBEDNRACCR2PPARGSERPINE1 | |
| SCHEMBL2562869 | 0.76 | KMT2A (0.74) | EDNRBEDNRATP53CCR2P2RX4 | |
| SCHEMBL6302627 | 0.76 | TP53 (0.61) | EDNRBEDNRATP53CCR2P2RX4 | |
| SCHEMBL8902335 | 0.76 | EDNRB (0.80) | EDNRBEDNRA | |
| SCHEMBL8856902 | 0.76 | EDNRB (0.58) | EDNRBEDNRATP53CCR2SERPINE1 | |
| SCHEMBL19133607 | 0.74 | EDNRB (0.59) | EDNRBEDNRACCR2SERPINE1 | |
| SCHEMBL4591747 | 0.74 | EDNRB (0.61) | EDNRBEDNRATP53SERPINE1MAPK8 | |
| SCHEMBL6093344 | 0.72 | PPARG (0.65) | EDNRBEDNRAPPARGSERPINE1PLA2G2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0676959-A4 | ENDOTHELIN RECEPTOR ANTAGONISTS. | SMITHKLINE BEECHAM CORP (US) | 1996-01-03 | — | — | EP | disclosed |
| EP-0676959-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1995-10-18 | — | — | EP | disclosed |