Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 7/20 | 0.42 |
| ▸ | EDNRB | P24530 | 2/20 | 0.37 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.35 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | CASR | P41180 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9023540 | 0.78 | EDNRB (0.54) | EDNRAEDNRBPPARGPLA2G2A | |
| SCHEMBL9423408 | 0.67 | CNR2 (0.61) | KMT2ACASR | |
| SCHEMBL9023630 | 0.65 | KDM4E (0.40) | KDM4EGAAPLA2G2AKMT2A | |
| SCHEMBL6857637 | 0.63 | EDNRA (0.53) | EDNRAEDNRBPPARGKDM4EKMT2A | |
| SCHEMBL6807907 | 0.63 | AOC3 (0.51) | KDM4EGAAKMT2A | |
| SCHEMBL6301200 | 0.61 | MTNR1A (0.67) | KMT2ACASR | |
| SCHEMBL11436414 | 0.61 | L3MBTL1 (0.62) | CASR | |
| SCHEMBL9690719 | 0.61 | SLC6A9 (0.60) | PPARG | |
| SCHEMBL11436469 | 0.61 | L3MBTL1 (0.62) | CASR | |
| SCHEMBL11436413 | 0.61 | L3MBTL1 (0.62) | CASR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0676959-A4 | ENDOTHELIN RECEPTOR ANTAGONISTS. | SMITHKLINE BEECHAM CORP (US) | 1996-01-03 | — | — | EP | claimed |
| EP-0676959-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1995-10-18 | — | — | EP | claimed |