Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR2 | P50052 | 10/20 | 0.68 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.68 |
| ▸ | REN | P00797 | 2/20 | 0.64 |
| ▸ | TFPI | P10646 | 4/20 | 0.55 |
| ▸ | NPY1R | P25929 | 1/20 | 0.55 |
| ▸ | NPY2R | P49146 | 1/20 | 0.55 |
| ▸ | NPY4R | P50391 | 1/20 | 0.55 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Angiotensin Amide SCHEMBL9324 | 0.95 | AGTR2 (0.74) | AGTR2AGTR1RENNPY1RNPY2R | |
| Angiotensin Amide SCHEMBL8155919 | 0.95 | AGTR2 (0.74) | AGTR2AGTR1RENNPY1RNPY2R | |
| Angiotensin Amide SCHEMBL7337886 | 0.95 | AGTR2 (0.73) | AGTR2AGTR1RENNPY1RNPY2R | |
| Angiotensin Amide SCHEMBL9433448 | 0.95 | AGTR2 (0.73) | AGTR2AGTR1RENNPY1RNPY2R | |
| Angiotensin Ii SCHEMBL7415391 | 0.95 | AGTR2 (0.77) | AGTR2AGTR1REN | |
| Angiotensin Amide SCHEMBL2197068 | 0.94 | AGTR2 (0.73) | AGTR2AGTR1RENNPY1RNPY2R | |
| Angiotensin Amide SCHEMBL10495835 | 0.94 | AGTR2 (0.72) | AGTR2AGTR1RENNPY1RNPY2R | |
| Angiotensin Amide SCHEMBL23015107 | 0.94 | AGTR2 (0.71) | AGTR2AGTR1RENNPY1RNPY2R | |
| Angiotensin Amide SCHEMBL3850850 | 0.94 | AGTR2 (0.71) | AGTR2AGTR1RENNPY1RNPY2R | |
| Angiotensin Amide SCHEMBL5722115 | 0.93 | AGTR2 (0.75) | AGTR2AGTR1RENTFPINPY1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0619819-B1 | 1-ARYLHETEROARYLALKYL SUBSTITUTED-1H-1,2,4-TRIAZOLE COMPOUNDS FOR TREATMENT OF CIRCULATORY DISORDERS | SEARLE & CO (US) | 1996-06-12 | — | — | EP | disclosed |
| EP-0508445-B1 | 1-Arylheteroarylalkyl substituted-1H-1,2,4-triazole compounds for treatment of circulatory disorders | SEARLE & CO (US) | 1996-06-12 | — | — | EP | disclosed |