Angiotensin Amide

SCHEMBL9433448

CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(C)C.[CaH2]

nearest known ligand 0.73

Full drug profile on Sugi Atlas →

Predicted protein targets (top 8)

	gene	UniProt	supporting neighbours	confidence
▸	AGTR2	P50052	11/20	0.73

▸	AGTR1	P30556	3/20	0.73

▸	REN	P00797	2/20	0.69

▸	LNPEP	Q9UIQ6	2/20	0.58

▸	NPY1R	P25929	1/20	0.58

▸	NPY2R	P49146	1/20	0.58

▸	NPY4R	P50391	1/20	0.58

▸	NPY5R	Q15761	1/20	0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Angiotensin Amide SCHEMBL9324	0.99	AGTR2 (0.74)	AGTR2AGTR1RENLNPEPNPY1R
Angiotensin Amide SCHEMBL8155919	0.99	AGTR2 (0.74)	AGTR2AGTR1RENLNPEPNPY1R
Angiotensin Amide SCHEMBL7337886	0.99	AGTR2 (0.73)	AGTR2AGTR1RENLNPEPNPY1R
Angiotensin Amide SCHEMBL2197068	0.98	AGTR2 (0.73)	AGTR2AGTR1RENLNPEPNPY1R
Angiotensin Amide SCHEMBL10495835	0.98	AGTR2 (0.72)	AGTR2AGTR1RENLNPEPNPY1R
Angiotensin Amide SCHEMBL23015107	0.97	AGTR2 (0.71)	AGTR2AGTR1RENLNPEPNPY1R
Angiotensin Amide SCHEMBL3850850	0.97	AGTR2 (0.71)	AGTR2AGTR1RENLNPEPNPY1R
Angiotensin Amide SCHEMBL5722115	0.97	AGTR2 (0.75)	AGTR2AGTR1RENNPY1RNPY2R
Angiotensin Ii SCHEMBL513519	0.95	AGTR2 (0.82)	AGTR2AGTR1RENLNPEPNPY1R
Angiotensin Amide SCHEMBL9023554	0.95	AGTR2 (0.68)	AGTR2AGTR1RENNPY1RNPY2R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-5330987-A	Substituted pyridopyrimidinones and related heterocycles as angiotensin II antagonists	MERCK & CO., INC. (US)	1994-07-19	—	—	US	disclosed