Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | NQO2 | P16083 | 8/20 | 0.33 |
| ▸ | NQO1 | P15559 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | HTR6 | P50406 | 2/20 | 0.32 |
| ▸ | KAT2B | Q92831 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.31 |
| ▸ | TOP2A | P11388 | 1/20 | 0.30 |
| ▸ | HTR2A | P28223 | 1/20 | 0.30 |
| ▸ | HTR2C | P28335 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9025537 | 0.89 | TOP2A (0.36) | TOP2AHTR2AHTR2C | |
| SCHEMBL9032596 | 0.88 | NQO2 (0.46) | NQO2NQO1 | |
| SCHEMBL9023748 | 0.83 | NQO2 (0.40) | NQO2NQO1 | |
| SCHEMBL9024132 | 0.82 | ALDH1A1 (0.33) | HTTKDM4EALDH1A1HPGDKMT2A | |
| SCHEMBL9024054 | 0.81 | TOP2A (0.38) | HTTNQO2KDM4EALDH1A1HPGD | |
| SCHEMBL9023557 | 0.80 | MEN1 (0.34) | KMT2AMEN1 | |
| SCHEMBL9025183 | 0.77 | NQO2 (0.38) | NQO2NQO1TOP2A | |
| SCHEMBL8543080 | 0.77 | MAPT (0.35) | HTTNQO2KDM4EALDH1A1HPGD | |
| SCHEMBL9025524 | 0.76 | TOP2A (0.38) | NQO2NQO1TOP2A | |
| SCHEMBL9024397 | 0.76 | TOP2A (0.40) | NQO2NQO1TOP2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0347749-B1 | Pyrazoloacridone derivatives with anti-tumoral activity | KYOWA HAKKO KOGYO KK (JP) | 1996-04-24 | — | — | EP | disclosed |
| US-5079358-A | Humans; leukemia | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1992-01-07 | — | — | US | disclosed |
| EP-0347749-A2 | Pyrazoloacridone derivatives with anti-tumoral activity | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1989-12-27 | — | — | EP | disclosed |